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Published online before print June 3, 2004

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(Journal of Leukocyte Biology. 2004;76:195-202.)
© 2004 by Society for Leukocyte Biology

Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells

Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

¹Correspondence: University of Ulsan, College of Medicine, Asan Medical Center, 388-1 Pungnap-2 dong, Songpa-gu 138-736, Seoul, South Korea. E-mail: steadyhan{at}amc.seoul.kr

Oxidized low-density lipoprotein (OxLDL) is an inflammatory modulator in the atherosclerotic plaque. We examined the effect of lysophosphatidylcholine (lysoPC), a main phospholipid component of OxLDL, on inflammatory responses in human CD4 T cells. We found that lysoPC dose- and time-dependently increased expression of CXCR4, the chemokine receptor on CD4 T cells. This increase was inhibited by caffeic acid phenethyl ester or SN50, nuclear factor-B inhibitors, and also by suppression of G2A expression, the specific receptor for lysoPC, using antisense oligonucleotide. lysoPC enhanced CD4 T cell chemotaxis in response to stromal cell-derived factor-1 (SDF-1), the exclusive ligand for CXCR4. lysoPC also enhanced SDF-1-stimulated production of inflammatory cytokines interleukin-2 and interferon- by CD4 T cells activated by anti-CD3 immunoglobulin G. In conclusion, this study demonstrates that lysoPC directly modulates inflammatory responses in human CD4 T cells. The data suggest that the presence of lysoPC and SDF-1 in atherosclerotic lesions may trigger inflammatory responses mediated by CD4 T cells, which may play an important role in progression of atherosclerosis.

Key Words: SDF-1 • atherosclerosis • lysophosphatidyl-choline • CXCR4 • CD4 • CD4 T cells

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