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Originally published online as doi:10.1189/jlb.1103586 on March 2, 2004

Published online before print March 2, 2004
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(Journal of Leukocyte Biology. 2004;75:962-972.)
© 2004 by Society for Leukocyte Biology

The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement

Andrew D. Weinberg*,1, Dean E. Evans*, Colin Thalhofer*, Tom Shi* and Rodney A. Prell{dagger}

* Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Oregon; and
{dagger} Cell Genesys, Foster City, California

1 Correspondence: Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, 4805 N.E. Glisan, Portland, OR 97213. E-mail: andrew.weinberg{at}providence.org

OX40 (CD134), a membrane-bound member of the tumor necrosis factor-receptor superfamily, is expressed primarily on activated CD4+ T cells. Following engagement on the cell surface, OX40 delivers a costimulatory signal that leads to potent, proinflammatory effects. Engagement of OX40 during antigen (Ag)-specific stimulation of T cells leads to increased production of memory T cells, increased migration of Ag-specific T cells, enhanced cytokine production by effector T cells, and the ability to break peripheral T cell tolerance in vivo. Therefore, OX40 engagement in vivo could have important ramifications for the enhancement of vaccine strategies and inhibition of unwanted inflammation. This review summarizes the molecular and cellular events that occur following OX40 engagement during Ag-specific T cell activation.

Key Words: TNF-R • antigen-specific T cells • autoimmunity • tumor immunology




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