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Originally published online as doi:10.1189/jlb.0403194 on January 14, 2004

Published online before print January 14, 2004
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(Journal of Leukocyte Biology. 2004;75:422-427.)
© 2004 by Society for Leukocyte Biology

Regulation of TLR signaling and inflammation by SOCS family proteins

Akihiko Yoshimura1, Hiroyuki Mori Masanobu Ohishi, Daisuke Aki and Toshikatsu Hanada

Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

1 Correspondence: Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: yakihiko{at}bioreg.kyushu-u.ac.jp

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.

Key Words: cytokine • tyrosine kinase • Toll-like receptor • STAT • NF-{kappa}B • inflammatory bowel disease • rheumatoid antithesis • endotoxin




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