Journal of Leukocyte Biology
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Originally published online as doi:10.1189/jlb.0503195 on December 4, 2003

Published online before print December 4, 2003
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(Journal of Leukocyte Biology. 2004;75:413-421.)
© 2004 by Society for Leukocyte Biology

The roles of insulin and hyperglycemia in sepsis pathogenesis

Soren Kaeseler Andersen1, Jakob Gjedsted, Christian Christiansen and Else Tønnesen

Department of Anesthesiology and Intensive Care, Institute of Experimental Clinical Research. Aarhus University Hospital, Denmark

1Correspondence: Dept. of Anesthesiology and Intensive Care, Aarhus University Hospital, Building 21,1, Norrebrogade 44, 8000 Aarhus C, Denmark. E-mail: ska{at}akhphd.au.dk

Hyperglycemia is a risk marker of morbidity and mortality in acute critical illness, and insulin therapy seems to be beneficial in this patient group. Whether this is true for a population of sepsis patients, as such, has not been investigated in clinical trials, but evidence from in vitro studies and experimental sepsis suggests that this may be the case. The endocrinology of septic patients is characterized by a shift in the balance between insulin and its counter-regulatory hormones favoring the latter. This leads to prominent metabolic derangements composed of high release and low use of glucose, amino acids, and free fatty acids (FFA), resulting in increased blood levels of these substrates. Circulating, proinflammatory mediators further enhance this state of global catabolism. Increased levels of glucose and FFA have distinct effects on inflammatory signaling leading to additional release of proinflammatory mediators and endothelial and neutrophil dysfunction. Insulin has the inherent capability to counteract the metabolic changes observed in septic patients. Concomitantly, insulin therapy may act as a modulator of inflammatory pathways inhibiting the unspecific, inflammatory activation caused by metabolic substrates. Given these properties, insulin could conceivably be serving a dual purpose for the benefit of septic patients.

Key Words: metabolism • endocrinology • stress hyperglycemia • septic shock • immunology • inflammation




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