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Published online before print November 21, 2003

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(Journal of Leukocyte Biology. 2004;75:350-357.)
© 2004 by Society for Leukocyte Biology

Expression of CD30 and Ox40 on T lymphocyte subsets is controlled by distinct regulatory mechanisms

Holly M. Toennies^*, Jonathan M. Green^*, and Robert H. Arch^*,,1

Departments of
^* Medicine and
Pathology and Immunology, Washington University, School of Medicine, St. Louis, Missouri

¹ Correspondence: Washington University, School of Medicine, Campus Box 8052, 660 S. Euclid Ave., St. Louis, MO 63110. E-mail: arch{at}wustl.edu

Members of the TNF receptor (TNFR) superfamily are cell-surface proteins that can be found on most cell types including lymphocytes. Although some TNFR-related molecules are constitutively expressed, others, such as CD30 and Ox40, are induced upon activation of lymphocytes. CD30 and Ox40 are predominantly expressed on activated T helper (T_h)2 cells. Both receptors can activate c-Jun N-terminal kinase (JNK) and nuclear factor-B (NF-B) and have been suggested to play costimulatory roles in lymphocyte activation. To gain further insight into events triggered by both TNFR-related molecules, a detailed analysis of their expression patterns has been performed. We found that CD30 and Ox40 were coexpressed on T_h2 cells. However, in contrast to CD30, Ox40 was also expressed on T_h1 cells. Although expression of both receptors is augmented by interleukin-4, only CD30 expression is dependent on signal transducer and activator of transcription (STAT)-6-mediated signaling. Differences in the regulatory pathways controlling expression of CD30 and Ox40 suggest distinct, functional effects triggered by the two TNFR-related molecules during lymphocyte activation.

Key Words: surface receptor • T cell differentiation • signal transduction

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