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Published online before print October 2, 2003
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6/V
1+ T cells elicited by inflammation
* Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado; and
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut
2Correspondence: Integrated Department of Immunology, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206. E-mail: obrienr{at}njc.org
The V
6/V
1+ cells, the second murine T cell subset to arise in the thymus, express a nearly invariant T cell receptor (TCR), colonize select tissues, and expand preferentially in other tissues during inflammation. These cells are thought to help in regulating the inflammatory response. Until now, V6/V1+ cells have only been detectable indirectly, by expression of V6-encoding mRNA. Here, we report that 17D1, a monoclonal antibody, which detects the related epidermis-associated V5/V1+ TCR, will also bind the V6/V1+ cells if their TCR is first complexed to an anti-C antibody. Features of this special condition for recognition suggest the possibility that an alternate structure exists for the V6/V1 TCR, which is stabilized upon binding to the anti-C antibody. Using the 17D1 antibody as means to track this T cell subset by flow cytometry, we discovered that the response of V6/V1+ cells during inflammation often far exceeds that of other subsets and that the responding V6/V1+ cells display a strikingly uniform activation/memory phenotype compared with other T cell subsets.
Key Words: T cells • T cell receptors
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