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Originally published online as doi:10.1189/jlb.0103042 on November 21, 2003

Published online before print November 21, 2003
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(Journal of Leukocyte Biology. 2003;74:1056-1063.)
© 2003 by Society for Leukocyte Biology

TNF revisited: TNF-independent antitumor activity in sera of mice sensitized with Propionibacterium acnes and challenged with lipopolysaccharide

Günter Schwamberger1,2, Peter Hammerl2, Ernst Ferber, Marina Freudenberg and Chris Galanos

Max-Planck-Institut für Immunbiologie, Freiburg, Germany

1Correspondence at current address: Institute of Chemistry and Biochemistry, University of Salzburg, Hellbrunner Str. 34, A-5020 Salzburg, Austria. E-mail: gschwamberger{at}yahoo.de

Sera of mice sensitized with bacteria and subsequently challenged with lipopolysaccharide promote hemorrhagic necrosis of tumors in vivo and display cytotoxic activity against tumor cells in vitro, which has been attributed to the induction of tumor necrosis factor (TNF). Here, we describe the induction of a previously unrecognized antitumor activity in such sera, which is distinct from TNF but displays tumor-specific cytocidal activity in vitro as well as potent tumor-regressing activity in vivo. Biochemical analysis of this activity yielded a molecular mass of ~150 kDa, closely resembling a novel tumoricidal factor of murine macrophages (M{phi}) termed MTC 170 (M{phi} tumor cytotoxin, approximate molecular mass 170 kDa), which we have previously proposed to constitute a major effector pathway for the destruction of tumor cells by activated M{phi}.

Key Words: tumor immunology • macrophage • cytotoxicity • cytokines




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