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Originally published online as doi:10.1189/jlb.1102577 on June 16, 2003

Published online before print June 16, 2003
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(Journal of Leukocyte Biology. 2003;74:331-343.)
© 2003 by Society for Leukocyte Biology

Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function

Jesper Melchjorsen, Louise N. Sørensen and Søren R. Paludan1

Department of Medical Microbiology and Immunology, University of Aarhus, Denmark

1Correspondence: Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark. E-mail: srp{at}microbiology.au.dk

Recruitment and activation of leukocytes are important for elimination of microbes, including viruses, from infected areas. Chemokines constitute a group of bioactive peptides that regulate leukocyte migration and also contribute to activation of these cells. Chemokines are essential mediators of inflammation and important for control of viral infections. The profile of chemokine expression contributes to shaping the immune response during viral infection, whereas viral subversion of the chemokine system allows the virus to evade antiviral activities of the host. In this review, we discuss the role of chemokines in host-defense against virus infections, and we also look deeper into the virus-cell interactions that trigger chemokine expression as well as the cellular signaling cascades involved.

Key Words: host-defense • leukocytes • signal transduction • NF-{kappa}B • IRF-3




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