Journal of Leukocyte Biology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kumaraguru, U.
Right arrow Articles by Rouse, B. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kumaraguru, U.
Right arrow Articles by Rouse, B. T.
(Journal of Leukocyte Biology. 2003;73:574-583.)
© 2003 by Society for Leukocyte Biology

Toll-like receptor ligand links innate and adaptive immune responses by the production of heat-shock proteins

Udayasankar Kumaraguru, Christopher D. Pack and Barry T. Rouse

Department of Microbiology, University of Tennessee, Knoxville

Correspondence: Dr. Barry T. Rouse, Distinguished Professor of Microbiology, M409 Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996. E-mail: btr{at}utk.edu

The report shows that CpG can exert additional adjuvant effects by inducing cells that are normally inferior antigen (Ag)-presenting cells to participate in immune induction by cross-priming. Macrophages (M{phi}) exposed to protein Ag in the presence of bioactive CpG DNA released material that induced primary CD8+ T cell responses in DC-naïve T cell cultures. This cross-priming event was accompanied by up-regulation of the stress protein response as well as inflammatory cytokine expression in treated M{phi}. The material released was indicated to contain inducible heat shock protein-70 and epitope peptide, which in turn, were presented by dendritic cells (DCs) to responder T cells. Such an adjuvant effect by CpG may serve to salvage immunogenic material from otherwise inert depot cellular sites and additionally stimulate DCs to effectively cross-prime. The cross-priming, shown also to occur in vivo, may be particularly useful when Ag doses are low and have minimal opportunity for delivery to DCs for consequent direct priming.

Key Words: hsp70 • cross-priming • chaperone • DC • M{phi}




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. D. Johnson, J. Campisi, C. M. Sharkey, S. L. Kennedy, M. Nickerson, and M. Fleshner
Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72
J Appl Physiol, November 1, 2005; 99(5): 1789 - 1795.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. J. Quintana and I. R. Cohen
Heat Shock Proteins as Endogenous Adjuvants in Sterile and Septic Inflammation
J. Immunol., September 1, 2005; 175(5): 2777 - 2782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Zheng, M. He, M. Long, R. Blomgran, and O. Stendahl
Pathogen-Induced Apoptotic Neutrophils Express Heat Shock Proteins and Elicit Activation of Human Macrophages
J. Immunol., November 15, 2004; 173(10): 6319 - 6326.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the Society for Leukocyte Biology.