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(Journal of Leukocyte Biology. 2003;73:379-390.)
© 2003 by Society for Leukocyte Biology

Differentiation of stress, metabolism, communication, and defense responses following transplantation

Thomas F. Mueller^*, Chunyan Ma^*, James A. Lederer and David L. Perkins^*

^* Laboratory of Molecular Immunology, Department of Medicine, and
Laboratory of Immunology, Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts

Correspondence: Dr. David L Perkins, Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115. E-mail: dperkins{at}rics.bwh.harvard.edu

The biological complexity of allograft rejection and alloantigen-independent mechanisms is poorly understood. Therefore, we analyzed four components of the biological response following transplantation by global gene analysis. A comparative and kinetic approach was used to identify gene expression profiles. Biological processes were assigned to genes displaying the largest alterations in expression. Metabolism, stress response, and cell organization were the predominant, biological processes associated with ischemia and systemic stress. Innate and adaptive immune responses induced a transcriptional shift toward defense and cell communication. The kinetic analysis showed a shift from innate toward adaptive responses in the post-transplant course.

Key Words: molecular biology • gene regulation • rodent

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