| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Immunology Department, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City
Correspondence: Dr. Carlos Rosales, Department of Immunology, Instituto de Investigaciones Biomédicas—UNAM, Apto. Postal 70228, Cd. Universitaria, México D.F.—04510, Mexico. E-mail: carosal{at}servidor.unam.mx
Phagocytosis is the process whereby cells engulf large particles, usually over 0.5 µm in diameter. Phagocytosis is triggered by the interaction of opsonins that cover the particle to be internalized with specific receptors on the surface of the phagocyte. The best-studied phagocytic receptors include the Fc receptors (FcR) that bind to the Fc portion of immunoglobulins. Cross-linking of FcR on the phagocyte initiates a variety of signals, which lead through the reorganization of the actin cytoskeleton, and membrane remodeling, to the formation of the phagosome. From recent data, it is becoming clear that FcR-mediated phagocytosis occurs as a series of steps that are regulated in a nonlinear manner and that signaling for phagocytosis does not terminate when the phagosome is formed. Several lipid molecules localize around the nascent phagosome and function as initiators of important signaling pathways for the late stages of phagolysosome formation. In addition, the use of particular signaling molecules may change for different receptors and may also vary depending on the activation or differentiation state of the cell. This review focuses on this new information and presents a model of our present understanding of the signal transduction events that regulate phagocytosis mediated by FcR.
Key Words: neutrophil • macrophage • monocyte • immunoglobulin
This article has been cited by other articles:
|
|
 |
|
  J. S. Lee, W. M. Nauseef, A. Moeenrezakhanlou, L. M. Sly, S. Noubir, K. G. Leidal, J. M. Schlomann, G. Krystal, and N. E. Reiner Monocyte p110{alpha} phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production J. Leukoc. Biol., June 1, 2007; 81(6): 1548 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Majewski, T. O. Bose, F. C. M. Sille, A. M. Pollington, E. Fiebiger, and M. Boes Protein kinase C delta stimulates antigen presentation by Class II MHC in murine dendritic cells Int. Immunol., June 1, 2007; 19(6): 719 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Semple, R. Aslam, M. Kim, E. R. Speck, and J. Freedman Platelet-bound lipopolysaccharide enhances Fc receptor mediated phagocytosis of IgG-opsonized platelets Blood, June 1, 2007; 109(11): 4803 - 4805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. L. Lee, G. Cosio, K. Ireton, and S. Grinstein Role of CrkII in Fc{gamma} Receptor-mediated Phagocytosis J. Biol. Chem., April 13, 2007; 282(15): 11135 - 11143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Garcia-Garcia, E. J. Brown, and C. Rosales Transmembrane Mutations to Fc{gamma}RIIA Alter Its Association with Lipid Rafts: Implications for Receptor Signaling J. Immunol., March 1, 2007; 178(5): 3048 - 3058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-Y. Huang, D. R. Barreda, R. G. Worth, Z. K. Indik, M.-K. Kim, P. Chien, and A. D. Schreiber Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis J. Leukoc. Biol., December 1, 2006; 80(6): 1553 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Kim, H.-w. Kim, H. Jeon, P.-G. Suh, and S. H. Ryu Phospholipase D1 Regulates Cell Migration in a Lipase Activity-independent Manner J. Biol. Chem., June 9, 2006; 281(23): 15747 - 15756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Cheeseman, T. Ueyama, T. M. Michaud, K. Kashiwagi, D. Wang, L. A. Flax, Y. Shirai, D. J. Loegering, N. Saito, and M. R. Lennartz Targeting of Protein Kinase C-{epsilon} during Fc{gamma} Receptor-dependent Phagocytosis Requires the {epsilon}C1B Domain and Phospholipase C-{gamma}1 Mol. Biol. Cell, February 1, 2006; 17(2): 799 - 813. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Cotter, A. K. Zaiss, and D. A. Muruve Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1 J. Virol., December 1, 2005; 79(23): 14622 - 14631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herant, V. Heinrich, and M. Dembo Mechanics of neutrophil phagocytosis: behavior of the cortical tension J. Cell Sci., May 1, 2005; 118(9): 1789 - 1797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Herre, A. S. J. Marshall, E. Caron, A. D. Edwards, D. L. Williams, E. Schweighoffer, V. Tybulewicz, C. R. e Sousa, S. Gordon, and G. D. Brown Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages Blood, December 15, 2004; 104(13): 4038 - 4045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yamauchi, C. Kim, S. Li, C. C. Marchal, J. Towe, S. J. Atkinson, and M. C. Dinauer Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles J. Immunol., November 15, 2004; 173(10): 5971 - 5979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Qin, J. C. Edberg, A. W. Gibson, G. P. Page, L. Teng, and R. P. Kimberly Differential Gene Expression Modulated by the Cytoplasmic Domain of Fc{gamma}RIa (CD64) {alpha}-Chain J. Immunol., November 15, 2004; 173(10): 6211 - 6219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Sulahian, P. A. Pioli, K. Wardwell, and P. M. Guyre Cross-linking of Fc{gamma}R triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163 J. Leukoc. Biol., July 1, 2004; 76(1): 271 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krupa, H. Kato, M. A. Matthay, and A. K. Kurdowska Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury Am J Physiol Lung Cell Mol Physiol, June 1, 2004; 286(6): L1105 - L1113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Nichols, K. Haines, P. S. Myung, S. Newbrough, E. Myers, H. Jumaa, D. J. Shedlock, H. Shen, and G. A. Koretzky Macrophage activation and Fc{gamma} receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors J. Leukoc. Biol., March 1, 2004; 75(3): 541 - 552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Doyle, R. M. O'Connell, G. A. Miranda, S. A. Vaidya, E. K. Chow, P. T. Liu, S. Suzuki, N. Suzuki, R. L. Modlin, W.-C. Yeh, et al. Toll-like Receptors Induce a Phagocytic Gene Program through p38 J. Exp. Med., January 5, 2004; 199(1): 81 - 90. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
