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(Journal of Leukocyte Biology. 2002;72:440-446.)
© 2002 by Society for Leukocyte Biology

Orphan nuclear receptors in T lymphocyte development

You-Wen He

Department of Immunology, Duke University Medical Center, Durham, North Carolina

Correspondence: You-Wen He, M.D., Ph.D., Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710. E-mail: he000004{at}mc.duke.edu

Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development. The orphan nuclear receptor ROR{gamma} has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl-xL. ROR{gamma} is also required for the development of lymph nodes and Peyer’s patches. The orphan receptors Nur77 and Nor1 are involved in TCR-mediated cell death and thymocyte-negative selection. These studies provide novel insights into the molecular mechanisms of T lymphocyte development.

Key Words: thymocyte apoptosis • thymocyte differentiation • TCR-{alpha} rearrangement • ROR{gamma} • Nur-77 • negative selection




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