Department of Immunology, Duke University Medical Center, Durham, North Carolina
Correspondence: You-Wen He, M.D., Ph.D., Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710. E-mail: he000004{at}mc.duke.edu
Lymphocyte development is initiated from hematopoietic stem cells and
can be divided into multiple phenotypically distinct stages.
Transcription factors play important roles in programming the
developmental process of lymphocytes. Recent studies have identified
key roles of several orphan nuclear receptors in T lymphocyte
development. The orphan nuclear receptor ROR
has been shown to
promote thymocyte survival by activating the expression of
antiapoptotic protein Bcl-xL. ROR is also required for
the development of lymph nodes and Peyer’s patches. The orphan
receptors Nur77 and Nor1 are involved in TCR-mediated cell death and
thymocyte-negative selection. These studies provide novel insights into
the molecular mechanisms of T lymphocyte development.
Key Words: thymocyte apoptosis • thymocyte differentiation • TCR-
rearrangement • ROR • Nur-77 • negative selection
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