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(Journal of Leukocyte Biology. 2002;72:363-372.)
© 2002 by Society for Leukocyte Biology

Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses

Bo-Chin Chiu^*, Xiao-Zhou Shang^*, Valerie R. Stolberg, Eric Komuniecki and Stephen W. Chensue^*,

^* Department of Pathology, University of Michigan Medical School, Ann Arbor; and
Department of Pathology and Laboratory Medicine, Veterans Affairs Healthcare System, Ann Arbor, Michigan

Correspondence: Dr. Stephen W. Chensue, Pathology and Laboratory Medicine 113, VAAAHS, 2215 Fuller Road, Ann Arbor, MI 48105. E-mail: schensue{at}med.umich.edu

Chemokine receptor transcripts were defined among CD4+ T cells in lymph nodes of mice with type-1 and type-2 inflammation, respectively, elicited by mycobacterial and schistosomal Ag. CXCR3 and CCR6 transcripts were biased to type-1, and CCR4 transcripts increased in type-1 and type-2 populations. CCR3 and CCR5 signals were too weak to establish differences. CCR8 transcripts were not increased among unstimulated populations. Compared to naïve, type-1 and type-2 populations had reduced CCR7 and enhanced CXCR5 transcripts, consistent with a shift to memory cells. Subset depletion revealed that transcript expression was induced among CD44+ memory T cells. Surprisingly, CCR3 transcripts were enriched among CD44lo fractions. Ag stimulation augmented CXCR3, CCR4, and CCR8 but down-regulated CCR6 and CXCR5. CCR4 showed association with IFN-- and IL-4-producing cells, but other receptor transcripts were expressed among IFN-/IL-4 negative memory T cells. These studies provide several novel findings regarding Th cell chemokine receptor expression in vivo.

Key Words: Th1 • Th2 • granulomas

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