HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Domachowske, J. B. Articles by Rosenberg, H. F. Search for Related Content PubMed PubMed Citation Articles by Domachowske, J. B. Articles by Rosenberg, H. F.

(Journal of Leukocyte Biology. 2002;71:966-972.)
© 2002 by Society for Leukocyte Biology

Pulmonary eosinophilia in mice devoid of interleukin-5

Joseph B. Domachowske^*, Cynthia A. Bonville^*, Andrew J. Easton and Helene F. Rosenberg

^* Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York;
Department of Biology, University of Warwick, Coventry, United Kingdom; and
Eosinophil Pathoplysiology Section, Laboratory of Host Defenses, NIAID, NIH, Bethesda, Maryland

Correspondence: Helene F. Rosenberg, M.D., Senior Investigator and Head, Eosinophil Pathophysiology Section, LHD/NIAID/NIH, 9000 Rockville Pike, Bethesda, MD 20892. E-mail: hr2k{at}nih.gov

The biology of the eosinophilic leukocyte—development, recruitment, and prolonged existence in somatic tissues—has been linked almost invariably to the actions of the "eosinophil" cytokine, interleukin-5 (IL-5). Here we demonstrate that pulmonary eosinophilia can occur in the absence of IL-5, as morphologically normal eosinophils are recruited to the lungs of virus-infected IL-5 -/- mice with kinetics and sequelae that are indistinguishable from those of their IL-5 +/+ counterparts. We conclude that pulmonary eosinophilia observed in response to primary paramyxovirus infection occurs via mechanisms that are distinct from those involved in eosinophil responses to allergens and in asthma. Furthermore, the presence of functional eosinophils in IL-5 -/- mice suggests the possibility of developmentally distinct subsets of what has been presumed to be a homogeneous leukocyte population.

This article has been cited by other articles:

				J. Bystrom, T. A. Wynn, J. B. Domachowske, and H. F. Rosenberg Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow Blood, February 1, 2004; 103(3): 868 - 877. [Abstract] [Full Text] [PDF]

				T. R. Johnson, R. A. Parker, J. E. Johnson, and B. S. Graham IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge J. Immunol., February 15, 2003; 170(4): 2037 - 2045. [Abstract] [Full Text] [PDF]