| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Mayo Clinic Scottsdale, Scottsdale, Arizona;
American Museum of Natural History, New York, New York;
Department of Immunology and Rheumatology, Merck Research Laboratories, Rahway, New Jersey; and
Department of Respiratory Medicine, Second Hospital of Zhejiang University School of Medicine, Hangzhou, People’s Republic of China
Correspondence: J. J. Lee, Ph.D., Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Samuel C. Johnson Medical Research Building—Research, Mayo Clinic Scottsdale, 13400 E. Shea Boulevard, Scottsdale, AZ 85259. E-mail: jlee{at}mayo.edu
Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interactions also appear to mediate eosinophil recruitment. The availability of genetically unique strains of mice permits a reductionist approach to assess the signaling pathways in experimental models of human disease. However, despite similarities in these pathways between mice and humans, significant species differences exist, complicating the translation of results from animal models to humans. Purified mouse eosinophils were used in this study to investigate the chemokine receptor expression and the activities of 18 chemokines. Mouse eosinophils isolated from IL-5 transgenic mice expressed transcripts encoding the chemokine receptors CCR1, CCR2, CCR3, CCR5, CCR8, CXCR2, and CXCR4, but not CCR4. Mouse eosinophils also migrated in response to human and mouse eotaxin-1 and -2, but not human eotaxin-3. In addition, the induced migration of mouse eosinophils by TARC, MIP-1ß, and KC suggests that unidentified receptor-ligand interactions contribute to eosinophil recruitment. It is interesting that the potent chemoattractant of human eosinophils, RANTES, was unable to mediate mouse eosinophil migration. Furthermore, despite the ability of MIP-1
to bind receptors on purified mouse eosinophils, it was only able to induce significant eosinophil migration in a mixed splenocyte population and was unable to induce migration of highly purified eosinophils. Collectively, these observations reveal physiologically relevant distinctions in mechanisms mediating human and mouse eosinophil migration that potentially reflect evolutionary disparities between these species.
Key Words: eotaxin • TARC • KC • MIP-1 • RANTES
This article has been cited by other articles:
|
|
 |
|
  Z. Li, S. Garantziotis, W. Jia, E. N. Potts, S. Lalani, Z. Liu, Y.-W. He, W. M. Foster, and J. W. Hollingsworth The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace J. Leukoc. Biol., January 1, 2009; 85(1): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Norris, M. E. Peterson, C. C. Stebbins, B. W. McConchie, V. G. Bundoc, S. Trivedi, M. G. Hodges, R. M. Anthony, J. F. Urban Jr, E. O. Long, et al. Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation J. Leukoc. Biol., December 1, 2007; 82(6): 1531 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Abdala-Valencia, J. Earwood, S. Bansal, M. Jansen, G. Babcock, B. Garvy, M. Wills-Karp, and J. M. Cook-Mills Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1111 - L1125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Whitehead, T. Wang, L. M. DeGraff, J. W. Card, S. A. Lira, G. J. Graham, and D. N. Cook The Chemokine Receptor D6 Has Opposing Effects on Allergic Inflammation and Airway Reactivity Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 243 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Galioto, J. A. Hess, T. J. Nolan, G. A. Schad, J. J. Lee, and D. Abraham Role of Eosinophils and Neutrophils in Innate and Adaptive Protective Immunity to Larval Strongyloides stercoralis in Mice. Infect. Immun., October 1, 2006; 74(10): 5730 - 5738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Gwinn, J. M. Damsker, R. Falahati, I. Okwumabua, A. Kelly-Welch, A. D. Keegan, C. Vanpouille, J. J. Lee, L. A. Dent, D. Leitenberg, et al. Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention J. Immunol., October 1, 2006; 177(7): 4870 - 4879. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Das, K. G. Vaddi, K. A. Solomon, C. Krauthauser, X. Jiang, K. W. McIntyre, X. X. Yang, E. Wadman, P. Welch, M. Covington, et al. Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation J. Pharmacol. Exp. Ther., July 1, 2006; 318(1): 411 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Cronshaw, A. Kouroumalis, R. Parry, A. Webb, Z. Brown, and S. G. Ward Evidence that phospholipase C-dependent, calcium-independent mechanisms are required for directional migration of T lymphocytes in response to the CCR4 ligands CCL17 and CCL22 J. Leukoc. Biol., June 1, 2006; 79(6): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Cormier, A. G. Taranova, C. Bedient, T. Nguyen, C. Protheroe, R. Pero, D. Dimina, S. I. Ochkur, K. O'Neill, D. Colbert, et al. Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response J. Leukoc. Biol., June 1, 2006; 79(6): 1131 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pang, M. Nie, L. Corbett, A. Sutcliffe, and A. J. Knox Mast Cell beta-Tryptase Selectively Cleaves Eotaxin and RANTES and Abrogates Their Eosinophil Chemotactic Activities J. Immunol., March 15, 2006; 176(6): 3788 - 3795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. J. Young, J. G. Molina, D. Dimina, H. Zhong, M. Jacobson, L.-N. L. Chan, T.-S. Chan, J. J. Lee, and M. R. Blackburn A3 Adenosine Receptor Signaling Contributes to Airway Inflammation and Mucus Production in Adenosine Deaminase-Deficient Mice J. Immunol., July 15, 2004; 173(2): 1380 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Erpenbeck, A. Hagenberg, Y. Dulkys, J. Elsner, R. Balder, H. Krentel, M. Discher, A. Braun, N. Krug, and J. M. Hohlfeld Natural Porcine Surfactant Augments Airway Inflammation after Allergen Challenge in Patients with Asthma Am. J. Respir. Crit. Care Med., March 1, 2004; 169(5): 578 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Haynes, L. P. Jones, A. Barskey, L. J. Anderson, and R. A. Tripp Enhanced Disease and Pulmonary Eosinophilia Associated with Formalin-Inactivated Respiratory Syncytial Virus Vaccination Are Linked to G Glycoprotein CX3C-CX3CR1 Interaction and Expression of Substance P J. Virol., September 15, 2003; 77(18): 9831 - 9844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. Lukacs, A. L. Miller, and C. M. Hogaboam Chemokine Receptors in Asthma: Searching for the Correct Immune Targets J. Immunol., July 1, 2003; 171(1): 11 - 15. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
