,**
* Department of Molecular Histopathology, and
|| Immunology, Department of Pathology, University of Cambridge, United Kingdom; Departments of
Microbiology and
# Medicine, University of Pennsylvania, Philadelphia;
The Wistar Institute, Philadelphia, Pennsylvania; and
Dept. of Microbiology, Immunology & Molecular Genetics, UCLA School of Medicine, and
** UCLA AIDS Institute, Los Angeles, California
Correspondence: Benhur Lee, M.D., Dept. of Microbiology, Immunology & Molecular Genetics, UCLA School of Medicine, and UCLA AIDS Institute, 3825 Molecular Sciences Building, 609 Charles E. Young Drive East, Los Angeles, California 90095-1489. E-mail: benhurL{at}microbio.ucla.edu
DC-SIGN is a C-type lectin, highly expressed on the surface of immature dendritic cells (DCs), that mediates efficient infection of T cells in trans by its ability to bind HIV-1, HIV-2, and SIV. In addition, the ability of DC-SIGN to bind adhesion molecules on surfaces of naïve T cells and endothelium also suggests its involvement in T-cell activation and DC trafficking. To gain further insights into the range of expression and potential functions of DC-SIGN, we performed a detailed analysis of DC-SIGN expression in adult and fetal tissues and also analyzed its regulated expression on cultured DCs and macrophages. First, we show that DC-SIGN expression is restricted to subsets of immature DCs in tissues and on specialized macrophages in the placenta and lung. There were no overt differences between DC-SIGN expression in adult and fetal tissues except that DC-SIGN expression in alveolar macrophages was only present after birth. Similarly, in tissues, DC-SIGN was observed primarily on immature (CD83-negative) DCs. Secondly, in the peripheral blood, we found expression of DC-SIGN on a small subset of BDCA-2+ plasmacytoid DC precursors (pDC2), concordant with our finding of large numbers of DC-SIGN-positive cells in allergic nasal polyps (previously shown to be infiltrated by DC2). Triple-label confocal microscopy indicated that DC-SIGN was colocalized with BDCA-2 and CD123 on DCs in nasal polyp tissue. Consistent with this finding is our observation that DC-SIGN can be up-regulated on monocyte-derived macrophages upon exposure to the Th2 cytokine, IL-13. In summary, our data demonstrate the relevant populations of DC and macrophages that express DC-SIGN in vivo where it may impact the efficiency of virus infection and indicate that DC-SIGN expression may be involved in the Th2 axis of immunity.
Key Words: lectin • HIV • BDCA-2 • Th1/Th2 • plasmacytoid
Related Articles
J. Leukoc. Biol. 2007 81: 369-371.
J. Leukoc. Biol. 2006 79: 1-3.
J. Leukoc. Biol. 2005 77: 1-2.
This article has been cited by other articles:
 |
|
 |
|
  N. P. Y. Chung, S. K. J. Breun, A. Bashirova, J. G. Baumann, T. D. Martin, J. M. Karamchandani, J. W. Rausch, S. F. J. Le Grice, L. Wu, M. Carrington, et al. HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN) J. Biol. Chem., January 15, 2010; 285(3): 2100 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Jain, S. L. Manuel, Z. K. Khan, J. Ahuja, K. Quann, and B. Wigdahl DC-SIGN Mediates Cell-Free Infection and Transmission of Human T-Cell Lymphotropic Virus Type 1 by Dendritic Cells J. Virol., November 1, 2009; 83(21): 10908 - 10921. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tanne, B. Ma, F. Boudou, L. Tailleux, H. Botella, E. Badell, F. Levillain, M. E. Taylor, K. Drickamer, J. Nigou, et al. A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis J. Exp. Med., September 28, 2009; 206(10): 2205 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Eljaafari, Y.-P. Li, and P. Miossec IFN-{gamma}, as Secreted during an Alloresponse, Induces Differentiation of Monocytes into Tolerogenic Dendritic Cells, Resulting in FoxP3+ Regulatory T Cell Promotion J. Immunol., September 1, 2009; 183(5): 2932 - 2945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kashima, E. S. Rodrigues, R. Azevedo, E. da Cruz Castelli, C. T. Mendes-Junior, F. K. N. Yoshioka, I. T. da Silva, O. M. Takayanagui, and D. T. Covas DC-SIGN (CD209) gene promoter polymorphisms in a Brazilian population and their association with human T-cell lymphotropic virus type 1 infection J. Gen. Virol., April 1, 2009; 90(4): 927 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Angel, C.-J. J. Chen, O. C. Horlacher, S. Winkler, T. John, J. Browning, D. MacGregor, J. Cebon, and P. R. Dunbar Distinctive localization of antigen-presenting cells in human lymph nodes Blood, February 5, 2009; 113(6): 1257 - 1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Salim, M. A. Silva, A. V. Keita, M. Larsson, P. Andersson, K.-E. Magnusson, M. H. Perdue, and J. D. Soderholm CD83+CCR7- Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyer's Patches of Ileal Crohn's Disease Am. J. Pathol., January 1, 2009; 174(1): 82 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Lambert, J. Desbarats, N. Arbour, J. A. Hall, A. Olivier, A. Bar-Or, and J. P. Antel Dendritic Cell Differentiation Signals Induce Anti-Inflammatory Properties in Human Adult Microglia J. Immunol., December 15, 2008; 181(12): 8288 - 8297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Cannon, Y. Yi, H. Ni, E. Stoddard, D. A. Scales, D. I. Van Ryk, I. Chaiken, D. Malamud, and D. Weissman HIV Envelope Binding by Macrophage-Expressed gp340 Promotes HIV-1 Infection J. Immunol., August 1, 2008; 181(3): 2065 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamakawa, C. Pennelegion, S. Willcocks, A. Stalker, N. MacHugh, D. Burt, T. J. Coffey, and D. Werling Identification and functional characterization of a bovine orthologue to DC-SIGN J. Leukoc. Biol., June 1, 2008; 83(6): 1396 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Tacken, B. Joosten, A. Reddy, D. Wu, A. Eek, P. Laverman, A. Kretz-Rommel, G. J. Adema, R. Torensma, and C. G. Figdor No Advantage of Cell-Penetrating Peptides over Receptor-Specific Antibodies in Targeting Antigen to Human Dendritic Cells for Cross-Presentation J. Immunol., June 1, 2008; 180(11): 7687 - 7696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Higgins, J. Sanchez-Campillo, A. G. Rosas-Taraco, J. R. Higgins, E. J. Lee, I. M. Orme, and M. Gonzalez-Juarrero Relative Levels of M-CSF and GM-CSF Influence the Specific Generation of Macrophage Populations during Infection with Mycobacterium tuberculosis J. Immunol., April 1, 2008; 180(7): 4892 - 4900. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Serrano-Gomez, E. Sierra-Filardi, R. T. Martinez-Nunez, E. Caparros, R. Delgado, M. A. Munoz-Fernandez, M. A. Abad, J. Jimenez-Barbero, M. Leal, and A. L. Corbi Structural Requirements for Multimerization of the Pathogen Receptor Dendritic Cell-specific ICAM3-grabbing Non-integrin (CD209) on the Cell Surface J. Biol. Chem., February 15, 2008; 283(7): 3889 - 3903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W.-P. Hong, S. Nguyen, S. Young, S. V. Su, and B. Lee Identification of the Optimal DC-SIGN Binding Site on Human Immunodeficiency Virus Type 1 gp120 J. Virol., August 1, 2007; 81(15): 8325 - 8336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dominguez-Soto, L. Aragoneses-Fenoll, E. Martin-Gayo, L. Martinez-Prats, M. Colmenares, M. Naranjo-Gomez, F. E. Borras, P. Munoz, M. Zubiaur, M. L. Toribio, et al. The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells Blood, June 15, 2007; 109(12): 5337 - 5345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gu and C. Korteweg Pathology and Pathogenesis of Severe Acute Respiratory Syndrome Am. J. Pathol., April 1, 2007; 170(4): 1136 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Perros, P. Dorfmuller, R. Souza, I. Durand-Gasselin, S. Mussot, M. Mazmanian, P. Herve, D. Emilie, G. Simonneau, and M. Humbert Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension Eur. Respir. J., March 1, 2007; 29(3): 462 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-H. Wang, A. M. Janas, W. J. Olson, V. N. KewalRamani, and L. Wu CD4 Coexpression Regulates DC-SIGN-Mediated Transmission of Human Immunodeficiency Virus Type 1 J. Virol., March 1, 2007; 81(5): 2497 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes J. Virol., March 1, 2007; 81(5): 2297 - 2306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Gijzen, P. J. Tacken, A. Zimmerman, B. Joosten, I. J. M. de Vries, C. G. Figdor, and R. Torensma Relevance of DC-SIGN in DC-induced T cell proliferation J. Leukoc. Biol., March 1, 2007; 81(3): 729 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ye, B. Zhang, J. Xu, Q. Chang, M. A. McNutt, C. Korteweg, E. Gong, and J. Gu Molecular Pathology in the Lungs of Severe Acute Respiratory Syndrome Patients Am. J. Pathol., February 1, 2007; 170(2): 538 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lissandrini, W. Vermi, M. Vezzalini, S. Sozzani, F. Facchetti, G. Bellone, A. Mafficini, F. Gentili, M. G. Ennas, C. Tecchio, et al. Receptor-type protein tyrosine phosphatase gamma (PTP{gamma}), a new identifier for myeloid dendritic cells and specialized macrophages Blood, December 15, 2006; 108(13): 4223 - 4231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Vacca, G. Pietra, M. Falco, E. Romeo, C. Bottino, F. Bellora, F. Prefumo, E. Fulcheri, P. L. Venturini, M. Costa, et al. Analysis of natural killer cells isolated from human decidua: evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function Blood, December 15, 2006; 108(13): 4078 - 4085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Davis, L. M. Mattei, H.-Y. Nguyen, C. Ansarah-Sobrinho, R. W. Doms, and T. C. Pierson The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin) J. Biol. Chem., December 1, 2006; 281(48): 37183 - 37194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Roulet, A.-P. Satie, A. Ruffault, A. L. Tortorec, H. Denis, O. Guist'hau, J.-J. Patard, N. Rioux-Leclerq, J. Gicquel, B. Jegou, et al. Susceptibility of Human Testis to Human Immunodeficiency Virus-1 Infection in Situ and in Vitro Am. J. Pathol., December 1, 2006; 169(6): 2094 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Donaghy, J. Wilkinson, and A. L. Cunningham HIV interactions with dendritic cells: has our focus been too narrow? J. Leukoc. Biol., November 1, 2006; 80(5): 1001 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Tschernig, V C de Vries, A S Debertin, A Braun, T Walles, F Traub, and R Pabst Density of dendritic cells in the human tracheal mucosa is age dependent and site specific Thorax, November 1, 2006; 61(11): 986 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chaipan, E. J. Soilleux, P. Simpson, H. Hofmann, T. Gramberg, A. Marzi, M. Geier, E. A. Stewart, J. Eisemann, A. Steinkasserer, et al. DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets J. Virol., September 15, 2006; 80(18): 8951 - 8960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Schulert and L.-A. H. Allen Differential infection of mononuclear phagocytes by Francisella tularensis: role of the macrophage mannose receptor J. Leukoc. Biol., September 1, 2006; 80(3): 563 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. K. Lai, P. J. Sun, J. Zhang, A. Jennings, P. F. Lalor, S. Hubscher, J. A. McKeating, and D. H. Adams Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium: A Role for Capturing Hepatitis C Virus Particles Am. J. Pathol., July 1, 2006; 169(1): 200 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Caminschi, A. J Corbett, C. Zahra, M. Lahoud, K. M Lucas, M. Sofi, D. Vremec, T. Gramberg, S. Pohlmann, J. Curtis, et al. Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN Int. Immunol., May 1, 2006; 18(5): 741 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-T. Yen, F. Liao, C.-H. Hsiao, C.-L. Kao, Y.-C. Chen, and B. A. Wu-Hsieh Modeling the Early Events of Severe Acute Respiratory Syndrome Coronavirus Infection In Vitro J. Virol., March 15, 2006; 80(6): 2684 - 2693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Davis, H.-Y. Nguyen, S. L. Hanna, M. D. Sanchez, R. W. Doms, and T. C. Pierson West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and Infection J. Virol., February 1, 2006; 80(3): 1290 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rappocciolo, F. J. Jenkins, H. R. Hensler, P. Piazza, M. Jais, L. Borowski, S. C. Watkins, and C. R. Rinaldo Jr DC-SIGN Is a Receptor for Human Herpesvirus 8 on Dendritic Cells and Macrophages J. Immunol., February 1, 2006; 176(3): 1741 - 1749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dakappagari, T. Maruyama, M. Renshaw, P. Tacken, C. Figdor, R. Torensma, M. A. Wild, D. Wu, K. Bowdish, and A. Kretz-Rommel Internalizing Antibodies to the C-Type Lectins, L-SIGN and DC-SIGN, Inhibit Viral Glycoprotein Binding and Deliver Antigen to Human Dendritic Cells for the Induction of T Cell Responses J. Immunol., January 1, 2006; 176(1): 426 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Meyer, E. van Liempt, A. Imberty, Y. van Kooyk, H. Geyer, R. Geyer, and I. van Die DC-SIGN Mediates Binding of Dendritic Cells to Authentic Pseudo-LewisY Glycolipids of Schistosoma mansoni Cercariae, the First Parasite-specific Ligand of DC-SIGN J. Biol. Chem., November 11, 2005; 280(45): 37349 - 37359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Papasavvas, J. Sun, Q. Luo, E. C. Moore, B. Thiel, R. R. MacGregor, A. Minty, K. Mounzer, J. R. Kostman, and L. J. Montaner IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes J. Immunol., October 15, 2005; 175(8): 5532 - 5540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Granelli-Piperno, A. Pritsker, M. Pack, I. Shimeliovich, J.-F. Arrighi, C. G. Park, C. Trumpfheller, V. Piguet, T. M. Moran, and R. M. Steinman Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction J. Immunol., October 1, 2005; 175(7): 4265 - 4273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dominguez-Soto, A. Puig-Kroger, M. A. Vega, and A. L. Corbi PU.1 Regulates the Tissue-specific Expression of Dendritic Cell-specific Intercellular Adhesion Molecule (ICAM)-3-grabbing Nonintegrin J. Biol. Chem., September 30, 2005; 280(39): 33123 - 33131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Tacken, I. J. M. de Vries, K. Gijzen, B. Joosten, D. Wu, R. P. Rother, S. J. Faas, C. J. A. Punt, R. Torensma, G. J. Adema, et al. Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody Blood, August 15, 2005; 106(4): 1278 - 1285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Goffard, N. Callens, B. Bartosch, C. Wychowski, F.-L. Cosset, C. Montpellier, and J. Dubuisson Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Glycoproteins J. Virol., July 1, 2005; 79(13): 8400 - 8409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Gurney, J. Elliott, H. Nassanian, C. Song, E. Soilleux, I. McGowan, P. A. Anton, and B. Lee Binding and Transfer of Human Immunodeficiency Virus by DC-SIGN+ Cells in Human Rectal Mucosa J. Virol., May 1, 2005; 79(9): 5762 - 5773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hunt, M. G. Petroff, R. H. McIntire, and C. Ober HLA-G and immune tolerance in pregnancy FASEB J, May 1, 2005; 19(7): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Vermi, E. Riboldi, V. Wittamer, F. Gentili, W. Luini, S. Marrelli, A. Vecchi, J.-D. Franssen, D. Communi, L. Massardi, et al. Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin J. Exp. Med., February 22, 2005; 201(4): 509 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marzi, T. Gramberg, G. Simmons, P. Moller, A. J. Rennekamp, M. Krumbiegel, M. Geier, J. Eisemann, N. Turza, B. Saunier, et al. DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus J. Virol., November 1, 2004; 78(21): 12090 - 12095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Serrano-Gomez, A. Dominguez-Soto, J. Ancochea, J. A. Jimenez-Heffernan, J. A. Leal, and A. L. Corbi Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin Mediates Binding and Internalization of Aspergillus fumigatus Conidia by Dendritic Cells and Macrophages J. Immunol., November 1, 2004; 173(9): 5635 - 5643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Rieger, A. Honig, M. Sutterlin, M. Kapp, J. Dietl, P. Ruck, and U. Kammerer Antigen-Presenting Cells in Human Endometrium During the Menstrual Cycle Compared to Early Pregnancy Reproductive Sciences, October 1, 2004; 11(7): 488 - 493. [Abstract] [PDF]
|
|
|
|
|
|
A. Puig-Kroger, D. Serrano-Gomez, E. Caparros, A. Dominguez-Soto, M. Relloso, M. Colmenares, L. Martinez-Munoz, N. Longo, N. Sanchez-Sanchez, M. Rincon, et al. Regulated Expression of the Pathogen Receptor Dendritic Cell-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin in THP-1 Human Leukemic Cells, Monocytes, and Macrophages J. Biol. Chem., June 11, 2004; 279(24): 25680 - 25688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ebner, Z. Ehammer, S. Holzmann, P. Schwingshackl, M. Forstner, P. Stoitzner, G. M. Huemer, P. Fritsch, and N. Romani Expression of C-type lectin receptors by subsets of dendritic cells in human skin Int. Immunol., June 1, 2004; 16(6): 877 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Galustian, C. G. Park, W. Chai, M. Kiso, S. A. Bruening, Y.-S. Kang, R. M. Steinman, and T. Feizi High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin Int. Immunol., June 1, 2004; 16(6): 853 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Engering, S. J. van Vliet, K. Hebeda, D. G. Jackson, R. Prevo, S. K. Singh, T. B. H. Geijtenbeek, H. van Krieken, and Y. van Kooyk Dynamic Populations of Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin-Positive Immature Dendritic Cells and Liver/Lymph Node-Specific ICAM-3 Grabbing Nonintegrin-Positive Endothelial Cells in the Outer Zones of the Paracortex of Human Lymph Nodes Am. J. Pathol., May 1, 2004; 164(5): 1587 - 1595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Liu, L. Tang, G. Zhang, H. Wei, Y. Cui, L. Guo, Z. Gou, X. Chen, D. Jiang, Y. Zhu, et al. Characterization of a Novel C-type Lectin-like Gene, LSECtin: DEMONSTRATION OF CARBOHYDRATE BINDING AND EXPRESSION IN SINUSOIDAL ENDOTHELIAL CELLS OF LIVER AND LYMPH NODE J. Biol. Chem., April 30, 2004; 279(18): 18748 - 18758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Su, P. Hong, S. Baik, O. A. Negrete, K. B. Gurney, and B. Lee DC-SIGN Binds to HIV-1 Glycoprotein 120 in a Distinct but Overlapping Fashion Compared with ICAM-2 and ICAM-3 J. Biol. Chem., April 30, 2004; 279(18): 19122 - 19132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J.-Y. Ploquin, O. M. Diop, N. Sol-Foulon, L. Mortara, A. Faye, M. A. Soares, E. Nerrienet, R. Le Grand, Y. Van Kooyk, A. Amara, et al. DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection in trans of Simian Immunodeficiency Virus SIVagm J. Virol., January 15, 2004; 78(2): 798 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Cole, N Coleman, and E Soilleux HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease J. Clin. Pathol., January 1, 2004; 57(1): 79 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Giordano, D. M. Magaletti, E. A. Clark, and J. A. Beavo Cyclic Nucleotides Promote Monocyte Differentiation Toward a DC-SIGN+ (CD209) Intermediate Cell and Impair Differentiation into Dendritic Cells J. Immunol., December 15, 2003; 171(12): 6421 - 6430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Klimstra, E. M. Nangle, M. S. Smith, A. D. Yurochko, and K. D. Ryman DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses J. Virol., November 15, 2003; 77(22): 12022 - 12032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Chehimi, Q. Luo, L. Azzoni, L. Shawver, N. Ngoubilly, R. June, G. Jerandi, M. Farabaugh, and L. J. Montaner HIV-1 transmission and cytokine-induced expression of DC-SIGN in human monocyte-derived macrophages J. Leukoc. Biol., November 1, 2003; 74(5): 757 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mohty, A. Vialle-Castellano, J. A. Nunes, D. Isnardon, D. Olive, and B. Gaugler IFN-{alpha} Skews Monocyte Differentiation into Toll-Like Receptor 7-Expressing Dendritic Cells with Potent Functional Activities J. Immunol., October 1, 2003; 171(7): 3385 - 3393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gardner and A. Moffett Dendritic Cells in the Human Decidua Biol Reprod, October 1, 2003; 69(4): 1438 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. Lozach, H. Lortat-Jacob, A. De Lacroix De Lavalette, I. Staropoli, S. Foung, A. Amara, C. Houles, F. Fieschi, O. Schwartz, J.-L. Virelizier, et al. DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2 J. Biol. Chem., May 23, 2003; 278(22): 20358 - 20366. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nobile, A. Moris, F. Porrot, N. Sol-Foulon, and O. Schwartz Inhibition of Human Immunodeficiency Virus Type 1 Env-Mediated Fusion by DC-SIGN J. Virol., May 1, 2003; 77(9): 5313 - 5323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pohlmann, J. Zhang, F. Baribaud, Z. Chen, G. J. Leslie, G. Lin, A. Granelli-Piperno, R. W. Doms, C. M. Rice, and J. A. McKeating Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR J. Virol., April 1, 2003; 77(7): 4070 - 4080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Gansert, V. Kiebler, M. Engele, F. Wittke, M. Rollinghoff, A. M. Krensky, S. A. Porcelli, R. L. Modlin, and S. Stenger Human NKT Cells Express Granulysin and Exhibit Antimycobacterial Activity J. Immunol., March 15, 2003; 170(6): 3154 - 3161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kammerer, A. O. Eggert, M. Kapp, A. D. McLellan, T. B. H. Geijtenbeek, J. Dietl, Y. van Kooyk, and E. Kampgen Unique Appearance of Proliferating Antigen-Presenting Cells Expressing DC-SIGN (CD209) in the Decidua of Early Human Pregnancy Am. J. Pathol., March 1, 2003; 162(3): 887 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Maeda, J. Nigou, J.-L. Herrmann, M. Jackson, A. Amara, P. H. Lagrange, G. Puzo, B. Gicquel, and O. Neyrolles The Cell Surface Receptor DC-SIGN Discriminates between Mycobacterium Species through Selective Recognition of the Mannose Caps on Lipoarabinomannan J. Biol. Chem., February 14, 2003; 278(8): 5513 - 5516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H.E. Kaufmann and U. E. Schaible A Dangerous Liaison between Two Major Killers: Mycobacterium tuberculosis and HIV Target Dendritic Cells through DC-SIGN J. Exp. Med., January 6, 2003; 197(1): 1 - 5. [Full Text] [PDF]
|
|
|
|
|
|
L. Tailleux, O. Schwartz, J.-L. Herrmann, E. Pivert, M. Jackson, A. Amara, L. Legres, D. Dreher, L. P. Nicod, J. C. Gluckman, et al. DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells J. Exp. Med., January 6, 2003; 197(1): 121 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Yu Kimata, M. Cella, J. E. Biggins, C. Rorex, R. White, S. Hicks, J. M. Wilson, P. G. Patel, J. S. Allan, M. Colonna, et al. Capture and Transfer of Simian Immunodeficiency Virus by Macaque Dendritic Cells Is Enhanced by DC-SIGN J. Virol., December 1, 2002; 76(23): 11827 - 11836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Engering, S. J. van Vliet, T. B. H. Geijtenbeek, and Y. van Kooyk Subset of DC-SIGN+ dendritic cells in human blood transmits HIV-1 to T lymphocytes Blood, August 13, 2002; 100(5): 1780 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. H. Geijtenbeek, A. Engering, and Y. van Kooyk DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology J. Leukoc. Biol., June 1, 2002; 71(6): 921 - 931. [Abstract] [Full Text] [PDF]
|
|
