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(Journal of Leukocyte Biology. 2002;71:381-387.)
© 2002 by Society for Leukocyte Biology

The role of growth hormone in T-cell development and reconstitution

Lisbeth A. Welniak, Rui Sun and William J. Murphy

Laboratory of Immunoregulation, NCI-Frederick and Intramural Research Support Program, SAIC, NCI-Frederick, Frederick, Maryland

Growth hormone (GH), directly or through GH-induction of insulin-like growth factor (IGF)-1, has been implicated in lymphocyte development and function. Recent studies have questioned the role of GH and IGF-1 in immune responses. This review examines experimental data describing the immunoregulatory function of GH and attempts to reconcile the literature.

Key Words: neuroendocrine hormones • thymus • dwarf • deficiency




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