| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Bone Marrow and Stem Cell Transplantation Program and Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis
Correspondence: Michael J. Robertson, M.D., Bone Marrow and Stem Cell Transplantation Program, 1044 W. Walnut Street, Room R4-202, Indianapolis, IN 46202. E-mail: mjrobert{at}iupui.edu
Natural killer (NK) cells participate in innate and adaptive immune responses to obligate intracellular pathogens and malignant tumors. Two major NK cell subsets have been identified in humans: CD56dim CD16+ and CD56bright CD16-. Resting CD56dim CD16+ NK cells express CXCR1, CXCR2, CXCR3, CXCR4, and CX3CR1 but no detectable levels of CC chemokine receptors on the cell surface. They migrate vigorously in response to CXCL12 and CXC3L1. In contrast, resting CD56bright CD16- NK cells express little CXCR1, CXCR2, and CXC3R1 but high levels of CCR5 and CCR7. Chemotaxis of CD56bright CD16- NK cells is stimulated most potently by CCL19, CCL21, CXCL10, CXCL11, and CXCL12. Following activation, NK cells can migrate in response to additional CC and CXC chemokines. Cytolytic activity of NK cells is augmented by CCL2, CCL3, CCL4, CCL5, CCL10, and CXC3L1. Moreover, proliferation of CD56dim CD16+ NK cells is costimulated by CCL19 and CCL21. Activated NK cells produce XCL1, CCL1, CCL3, CCL4, CCL5, CCL22, and CXCL8. Chemokines secreted by NK cells may recruit other effector cells during immune responses. Furthermore, CCL3, CCL4, and CCL5 produced by NK cells can inhibit in vitro replication of HIV. CCL3 and CXL10 expression appear to be required for protective NK cell responses in vivo to murine cytomegalovirus or Leishmania major, respectively. Moreover, NK cells participate in the in vivo rejection of transduced tumor cells that produce CCL19 or CCL21. Thus, chemokines appear to play an important role in afferent and efferent NK cell responses to infected and neoplastic cells.
Key Words: chemotaxis • cytotoxicity • proliferation
This article has been cited by other articles:
|
|
 |
|
  T. Kheradmand, P. P. Trivedi, N. A. Wolf, P. C. Roberts, and R. H. Swanborg Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats J. Leukoc. Biol., May 1, 2008; 83(5): 1128 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. Speetjens, P. J.K. Kuppen, M. H. Sandel, A. G. Menon, D. Burg, C. J.H. van de Velde, R. A.E.M. Tollenaar, H. J.G.M. de Bont, and J. F. Nagelkerke Disrupted Expression of CXCL5 in Colorectal Cancer Is Associated with Rapid Tumor Formation in Rats and Poor Prognosis in Patients Clin. Cancer Res., April 15, 2008; 14(8): 2276 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Vacher-Coponat, C. Brunet, L. Lyonnet, E. Bonnet, A. Loundou, J. Sampol, V. Moal, B. Dussol, P. Brunet, Y. Berland, et al. Natural killer cell alterations correlate with loss of renal function and dialysis duration in uraemic patients Nephrol. Dial. Transplant., April 1, 2008; 23(4): 1406 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shanker, G. Verdeil, M. Buferne, E.-M. Inderberg-Suso, D. Puthier, F. Joly, C. Nguyen, L. Leserman, N. Auphan-Anezin, and A.-M. Schmitt-Verhulst CD8 T Cell Help for Innate Antitumor Immunity J. Immunol., November 15, 2007; 179(10): 6651 - 6662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Zhang, P. Colmenero, U. Purath, C. Teixeira de Matos, W. Hueber, L. Klareskog, I. H. Tarner, E. G. Engleman, and K. Soderstrom Natural killer cells trigger differentiation of monocytes into dendritic cells Blood, October 1, 2007; 110(7): 2484 - 2493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cerboni, A. Zingoni, M. Cippitelli, M. Piccoli, L. Frati, and A. Santoni Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis Blood, July 15, 2007; 110(2): 606 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zamai, C. Ponti, P. Mirandola, G. Gobbi, S. Papa, L. Galeotti, L. Cocco, and M. Vitale NK Cells and Cancer J. Immunol., April 1, 2007; 178(7): 4011 - 4016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Vasquez and L. Soong CXCL10/Gamma Interferon-Inducible Protein 10-Mediated Protection against Leishmania amazonensis Infection in Mice Infect. Immun., December 1, 2006; 74(12): 6769 - 6777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Berahovich, N. L. Lai, Z. Wei, L. L. Lanier, and T. J. Schall Evidence for NK Cell Subsets Based on Chemokine Receptor Expression J. Immunol., December 1, 2006; 177(11): 7833 - 7840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Prat, J. Bestebroer, C. J. C. de Haas, J. A. G. van Strijp, and K. P. M. van Kessel A New Staphylococcal Anti-Inflammatory Protein That Antagonizes the Formyl Peptide Receptor-Like 1 J. Immunol., December 1, 2006; 177(11): 8017 - 8026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Page, S. R. Plymate, W. J. Bremner, A. M. Matsumoto, D. L. Hess, D. W. Lin, J. K. Amory, P. S. Nelson, and J. D. Wu Effect of medical castration on CD4+CD25+ T cells, CD8+ T cell IFN-{gamma} expression, and NK cells: a physiological role for testosterone and/or its metabolites Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E856 - E863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Wald, I. D. Weiss, H. Wald, H. Shoham, Y. Bar-Shavit, K. Beider, E. Galun, L. Weiss, L. Flaishon, I. Shachar, et al. IFN-{gamma} Acts on T Cells to Induce NK Cell Mobilization and Accumulation in Target Organs. J. Immunol., April 15, 2006; 176(8): 4716 - 4729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hanna, H. Mussaffi, G. Steuer, S. Hanna, M. Deeb, H. Blau, T. I. Arnon, N. Weizman, and O. Mandelboim Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency Blood, November 15, 2005; 106(10): 3465 - 3473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Svensson, S. Zubairi, A. Maroof, F. Kazi, M. Taniguchi, and P. M. Kaye Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection Infect. Immun., November 1, 2005; 73(11): 7541 - 7547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Woolard, D. Hudig, L. Tabor, J. A. Ivey, and J. W. Simecka NK Cells in Gamma-Interferon-Deficient Mice Suppress Lung Innate Immunity against Mycoplasma spp. Infect. Immun., October 1, 2005; 73(10): 6742 - 6751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Roda, R. Parihar, and W. E. Carson III CpG-Containing Oligodeoxynucleotides Act through TLR9 to Enhance the NK Cell Cytokine Response to Antibody-Coated Tumor Cells J. Immunol., August 1, 2005; 175(3): 1619 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. McInnis, A. Britain, R. N. Lausch, and J. E. Oakes Synthesis of {alpha}-Chemokines IP-10, I-TAC, and MIG Are Differentially Regulated in Human Corneal Keratocytes Invest. Ophthalmol. Vis. Sci., May 1, 2005; 46(5): 1668 - 1674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mavilio, G. Lombardo, J. Benjamin, D. Kim, D. Follman, E. Marcenaro, M. A. O'Shea, A. Kinter, C. Kovacs, A. Moretta, et al. Characterization of CD56-/CD16+ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals PNAS, February 22, 2005; 102(8): 2886 - 2891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kishimoto, M. Muramatsu, M. Gokoh, S. Oka, K. Waku, and T. Sugiura Endogenous Cannabinoid Receptor Ligand Induces the Migration of Human Natural Killer Cells J. Biochem., February 1, 2005; 137(2): 217 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Giroux and F. Denis CD1d-unrestricted human NKT cells release chemokines upon Fas engagement Blood, January 15, 2005; 105(2): 703 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Widney, Y. Hu, A. K. Foreman-Wykert, K. C. Bui, T. T. Nguyen, B. Lu, C. Gerard, J. F. Miller, and J. B. Smith CXCR3 and Its Ligands Participate in the Host Response to Bordetella bronchiseptica Infection of the Mouse Respiratory Tract but Are Not Required for Clearance of Bacteria from the Lung Infect. Immun., January 1, 2005; 73(1): 485 - 493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lavergne, C. Combadiere, M. Iga, A. Boissonnas, O. Bonduelle, M. Maho, P. Debre, and B. Combadiere Intratumoral CC Chemokine Ligand 5 Overexpression Delays Tumor Growth and Increases Tumor Cell Infiltration J. Immunol., September 15, 2004; 173(6): 3755 - 3762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sheikh, R. S. Parhar, R. Bakheet, S. Saleh, K. Collison, and F. Al-Mohanna Immobilization of rolling NK cells on platelet-borne P-selectin under flow by proinflammatory stimuli, interleukin-12, and leukotriene B4 J. Leukoc. Biol., September 1, 2004; 76(3): 603 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.G.M. Lukassen, I. Joosten, B. van Cranenbroek, M.J.C. van Lierop, J. Bulten, D.D.M. Braat, and A. van der Meer Hormonal stimulation for IVF treatment positively affects the CD56bright/CD56dim NK cell ratio of the endometrium during the window of implantation Mol. Hum. Reprod., July 1, 2004; 10(7): 513 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Megjugorac, H. A. Young, S. B. Amrute, S. L. Olshalsky, and P. Fitzgerald-Bocarsly Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells J. Leukoc. Biol., March 1, 2004; 75(3): 504 - 514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Doubrovina, M. M. Doubrovin, E. Vider, R. B. Sisson, R. J. O'Reilly, B. Dupont, and Y. M. Vyas Evasion from NK Cell Immunity by MHC Class I Chain-Related Molecules Expressing Colon Adenocarcinoma J. Immunol., December 15, 2003; 171(12): 6891 - 6899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mavilio, J. Benjamin, M. Daucher, G. Lombardo, S. Kottilil, M. A. Planta, E. Marcenaro, C. Bottino, L. Moretta, A. Moretta, et al. Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates PNAS, December 9, 2003; 100(25): 15011 - 15016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Barlic, J. M. Sechler, and P. M. Murphy IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1 Blood, November 15, 2003; 102(10): 3494 - 3503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Maghazachi G protein-coupled receptors in natural killer cells J. Leukoc. Biol., July 1, 2003; 74(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Kipriyanov, B. Cochlovius, H. J. Schafer, G. Moldenhauer, A. Bahre, F. Le Gall, S. Knackmuss, and M. Little Synergistic Antitumor Effect of Bispecific CD19 x CD3 and CD19 x CD16 Diabodies in a Preclinical Model of Non-Hodgkin's Lymphoma J. Immunol., July 1, 2002; 169(1): 137 - 144. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
