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Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Correspondence: Lei Yao, Experimental Transplantation and Immunology Branch, National Cancer Institute, Building 10, Room 12N226, MSC 1907, Bethesda, Maryland 20892. E-mail: yaol{at}mail.nih.gov
Vasostatin, the 1–180 amino acids NH2 domain of
calreticulin, inhibits endothelial cell proliferation, angiogenesis,
and tumor growth, but the mechanisms underlying these effects are
unclear. We show that endothelial cells express the extracellular
matrix protein laminin, including chains 
5 and 
1 and that
vasostatin specifically binds to laminin. When added to endothelial
cell cultures, vasostatin specifically inhibits endothelial cell
attachment to laminin and by this mechanism, can reduce subsequent
endothelial cell growth induced by basic fibroblast growth factor. As
an angiogenesis inhibitor that specifically disrupts endothelial cell
attachment to components of the extracellular matrix, vasostatin has a
unique potential as a cancer therapeutic.
Key Words: angiogenesis • extracellular matrix • laminin
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