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(Journal of Leukocyte Biology. 2001;70:793-800.)
© 2001 by Society for Leukocyte Biology

C1qR_P, a myeloid cell receptor in blood, is predominantly expressed on endothelial cells in human tissue

Maria I. Fonseca, Philip M. Carpenter^*, Minha Park, Gail Palmarini, Edward L. Nelson and Andrea J. Tenner

Departments of Molecular Biology and Biochemistry,
^* Pathology, and
Medicine, University of California, Irvine, Irvine, CA 92697

C1qR_P is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the molecule. C1qR_P was detected in vascular endothelial cells and in a subset of pyramidal neurons in the brain, as well as neutrophils, but it was absent in most tissue macrophages. Analysis of in vitro differentiation of blood monocytes to dendritic cells demonstrated a down-regulation of the receptor as monocytes differentiate to dendritic cells, providing a possible explanation for the lack of reactivity of these cells in tissue. The predominant presence of C1qR_P in endothelial cells, while compatible with a phagocytic role in host defense and/or clearance of cellular material, suggests other possible novel roles for this receptor.

Key Words: complement • phagocytosis • dendritic cells • receptor • monocytes • neutrophils

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