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* U365 INSERM,
Section de Recherche, Institut Curie
U546 INSERM, Hôpital La Pitié-Salpêtrière, Paris, France
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Salvador-Bahia, Brazil
Although interferon (IFN)-ß has shown a significant clinical benefit in multiple sclerosis (MS), its mechanism of action remains unclear. We found that IFN-ß treatment of patients with MS resulted in a significant increase in apoptotic cell death (measured by annexin V staining and nuclear fragmentation) of monocyte-derived macrophages, as compared with cells derived from patients before treatment. Stimulation of the cells with IFN-ß in vitro resulted in an even further increase of annexin V binding, as well as increased Fas (CD 95, APO-1) expression. However, no increased Fas expression, apoptotic monocytes, or monocytopenia were observed upon in vivo treatment. This indicates that IFN-ß does not deliver a death signal to monocytes but rather primes for subsequent macrophage apoptosis upon activation or differentiation.
Key Words: in vivo CD 14 CD 64 CD 95 (Fas)
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