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(Journal of Leukocyte Biology. 2001;70:737-744.)
© 2001 by Society for Leukocyte Biology

Profound effect of the absence of IL-4 on T cell responses during infection with Schistosoma mansoni

João A. Pedras-Vasconcelos, Laura Rosa Brunet and Edward J. Pearce

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY

Correspondence: Dr. Edward J. Pearce, Department of Microbiology and Immunology, C5-165 VMC, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401.

T cell responses of interleukin (IL)-4-/- and wild-type (WT) mice infected with the helper T cell 2 (Th2) response-inducing pathogen Schistosoma mansoni were compared. As expected, given the important role of IL-4 in Th2 response induction, the absence of IL-4 resulted in diminished Th2 responses, apparent as reduced production of IL-4, -5, and -10 by CD4+ cells isolated from the spleens of infected IL-4-/- mice. Surprisingly, these cells produced significantly less interferon (IFN)-{gamma} and proliferated less than did those from infected WT mice after T cell receptor ligation. CD8+ cells isolated from infected IL-4-/- mice also produced less IFN-{gamma} than WT CD8 cells, although there was no difference in the proliferative responses of these cell populations. After infection, spleens of infected IL-4-/- mice did not enlarge to the same extent as those of WT mice, and attrition of the CD8+ cell population within this lymphoid organ was noted. Taken together, the data indicate that in addition to inhibiting Th2 response development, the lack of IL-4 during schistosomiasis significantly affects additional aspects of T cell responses.

Key Words: helminth parasite • Th1/Th2 • proliferation • apoptosis




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