| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Eosinophil Biology Unit, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; and
Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York
Correspondence: Helene F. Rosenberg, M.D., EBU, Laboratory of Host Defenses, Building 10, Room 11N104, NIAID, NIH, Bethesda, Maryland 20892. E-mail: hr2k{at}nih.gov
Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities—e.g., asthma and allergic disease—far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil-associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single-stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil-mediated double-edged sword.
Key Words: pneumonia virus of mice • major basic protein
This article has been cited by other articles:
|
|
 |
|
  K. D. Dyer, J. M. Moser, M. Czapiga, S. J. Siegel, C. M. Percopo, and H. F. Rosenberg Functionally Competent Eosinophils Differentiated Ex Vivo in High Purity from Normal Mouse Bone Marrow J. Immunol., September 15, 2008; 181(6): 4004 - 4009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. R. Johnson, M. E. Rothenberg, and B. S. Graham Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein J. Leukoc. Biol., September 1, 2008; 84(3): 748 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yoon, J. U. Ponikau, C. B. Lawrence, and H. Kita Innate Antifungal Immunity of Human Eosinophils Mediated by a {beta}2 Integrin, CD11b J. Immunol., August 15, 2008; 181(4): 2907 - 2915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Rosenberg RNase A ribonucleases and host defense: an evolving story J. Leukoc. Biol., May 1, 2008; 83(5): 1079 - 1087. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Gaudreault and J. Gosselin Leukotriene B4 Induces Release of Antimicrobial Peptides in Lungs of Virally Infected Mice J. Immunol., May 1, 2008; 180(9): 6211 - 6221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Yang, Q. Chen, S. B. Su, P. Zhang, K. Kurosaka, R. R. Caspi, S. M. Michalek, H. F. Rosenberg, N. Zhang, and J. J. Oppenheim Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J. Exp. Med., January 21, 2008; 205(1): 79 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Y. Liu, M. E. Bates, N. N. Jarjour, W. W. Busse, P. J. Bertics, and E. A. B. Kelly Generation of Th1 and Th2 Chemokines by Human Eosinophils: Evidence for a Critical Role of TNF-{alpha} J. Immunol., October 1, 2007; 179(7): 4840 - 4848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Phipps, C. E. Lam, S. Mahalingam, M. Newhouse, R. Ramirez, H. F. Rosenberg, P. S. Foster, and K. I. Matthaei Eosinophils contribute to innate antiviral immunity and promote clearance of respiratory syncytial virus Blood, September 1, 2007; 110(5): 1578 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Monteseirin, A. Vega, P. Chacon, M. J. Camacho, R. El Bekay, J. A. Asturias, A. Martinez, P. Guardia, R. Perez-Cano, and J. Conde Neutrophils as a Novel Source of Eosinophil Cationic Protein in IgE-Mediated Processes J. Immunol., August 15, 2007; 179(4): 2634 - 2641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Tumes, J. Cormie, M. G. Calvert, K. Stewart, C. Nassenstein, A. Braun, P. S. Foster, and L. A. Dent Strain-dependent resistance to allergen-induced lung pathophysiology in mice correlates with rate of apoptosis of lung-derived eosinophils J. Leukoc. Biol., June 1, 2007; 81(6): 1362 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Polydoridis, D. D. Leonidas, N. G. Oikonomakos, and G. Archontis Recognition of Ribonuclease A by 3'-5'-Pyrophosphate-Linked Dinucleotide Inhibitors: A Molecular Dynamics/Continuum Electrostatics Analysis Biophys. J., March 1, 2007; 92(5): 1659 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Nitto, K. D. Dyer, M. Czapiga, and H. F. Rosenberg Evolution and Function of Leukocyte RNase A Ribonucleases of the Avian Species, Gallus gallus J. Biol. Chem., September 1, 2006; 281(35): 25622 - 25634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-F. Valarcher, J. Furze, S. G. Wyld, R. Cook, G. Zimmer, G. Herrler, and G. Taylor Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves J. Gen. Virol., June 1, 2006; 87(6): 1659 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U.-B. Jonsson, J. Bystrom, G. Stalenheim, and P. Venge A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP J. Leukoc. Biol., April 1, 2006; 79(4): 846 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. W. Claassen, P. A. A. van der Kant, Z. S. Rychnavska, G. M. van Bleek, A. J. Easton, and R. G. van der Most Activation and Inactivation of Antiviral CD8 T Cell Responses during Murine Pneumovirus Infection J. Immunol., November 15, 2005; 175(10): 6597 - 6604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Dyer and H. F. Rosenberg The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression Nucleic Acids Res., February 18, 2005; 33(3): 1077 - 1086. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, Q. Chen, H. F. Rosenberg, S. M. Rybak, D. L. Newton, Z. Y. Wang, Q. Fu, V. T. Tchernev, M. Wang, B. Schweitzer, et al. Human Ribonuclease A Superfamily Members, Eosinophil-Derived Neurotoxin and Pancreatic Ribonuclease, Induce Dendritic Cell Maturation and Activation J. Immunol., November 15, 2004; 173(10): 6134 - 6142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Levy Antimicrobial proteins and peptides: anti-infective molecules of mammalian leukocytes J. Leukoc. Biol., November 1, 2004; 76(5): 909 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Swartz, J. Bystrom, K. D. Dyer, T. Nitto, T. A. Wynn, and H. F. Rosenberg Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes J. Leukoc. Biol., October 1, 2004; 76(4): 812 - 819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Feistritzer, N. C. Kaneider, D. H. Sturn, B. A. Mosheimer, C. M. Kahler, and C. J. Wiedermann Expression and Function of the Vascular Endothelial Growth Factor Receptor FLT-1 in Human Eosinophils Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 729 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kariko, H. Ni, J. Capodici, M. Lamphier, and D. Weissman mRNA Is an Endogenous Ligand for Toll-like Receptor 3 J. Biol. Chem., March 26, 2004; 279(13): 12542 - 12550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, H. F. Rosenberg, Q. Chen, K. D. Dyer, K. Kurosaka, and J. J. Oppenheim Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells Blood, November 1, 2003; 102(9): 3396 - 3403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Espert, G. Degols, C. Gongora, D. Blondel, B. R. Williams, R. H. Silverman, and N. Mechti ISG20, a New Interferon-induced RNase Specific for Single-stranded RNA, Defines an Alternative Antiviral Pathway against RNA Genomic Viruses J. Biol. Chem., April 25, 2003; 278(18): 16151 - 16158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Johnson, R. A. Parker, J. E. Johnson, and B. S. Graham IL-13 Is Sufficient for Respiratory Syncytial Virus G Glycoprotein-Induced Eosinophilia After Respiratory Syncytial Virus Challenge J. Immunol., February 15, 2003; 170(4): 2037 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Adamko, A. D. Fryer, B. S. Bochner, and D. B. Jacoby CD8+ T Lymphocytes in Viral Hyperreactivity and M2 Muscarinic Receptor Dysfunction Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 550 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, K. D. Dyer, and H. F. Rosenberg Human RNase 7: a new cationic ribonuclease of the RNase A superfamily Nucleic Acids Res., January 15, 2003; 31(2): 602 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Domachowske, C. A. Bonville, A. J. Easton, and H. F. Rosenberg Pulmonary eosinophilia in mice devoid of interleukin-5 J. Leukoc. Biol., June 1, 2002; 71(6): 966 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Benner The past as the key to the present: Resurrection of ancient proteins from eosinophils PNAS, April 16, 2002; 99(8): 4760 - 4761. [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang and H. F. Rosenberg From the Cover: Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates PNAS, April 16, 2002; 99(8): 5486 - 5491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, K. D. Dyer, and H. F. Rosenberg RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta Nucleic Acids Res., March 1, 2002; 30(5): 1169 - 1175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang and H. F. Rosenberg From the Cover: Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates PNAS, April 16, 2002; 99(8): 5486 - 5491. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
