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(Journal of Leukocyte Biology. 2001;70:518-526.)
© 2001 by Society for Leukocyte Biology

V1 and V2 T cells express distinct surface markers and might be developmentally distinct lineages

Stephen C. De Rosa^*, Dipendra K. Mitra, Nobukazu Watanabe, Leonore A. Herzenberg, Leonard A. Herzenberg and Mario Roederer^*

^* Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, and
Department of Genetics, Stanford University Medical School, Stanford, California

Correspondence: Stephen C. De Rosa, M.D., Vaccine Research Center, National Institutes of Health, 40 Convent Drive, Room 5612, Bethesda, MD 20814. E-mail: SDeRosa{at}nih.gov

We report here that the two major types of T cells found in human blood, V1 and V2, were found to have markedly different phenotypes. V2 cells had a phenotype typical of most ß T cells in blood; i.e., they were CD5⁺, CD28⁺, and CD57^-. In contrast, V1 cells tended to be CD5^-/dull, CD28^-, and CD57⁺. Furthermore, although V1 T cells appeared to be "naive" in that they were CD45RA⁺, they were CD62L^- and on stimulation uniformly produced interferon-, indicating that they are in fact memory/effector cells. This phenotype for V1 cells was similar to that of intestinal intraepithelial lymphocytes, a subset that can develop in the absence of the thymus. We suggest that the V1 and V2 T cell subsets represent distinct lineages with different developmental pathways. The disruption of the supply of normal, thymus-derived T cells in HIV-infected individuals might be responsible for the shift in the V2/V1 ratio that occurs in the blood of individuals with HIV disease.

Key Words: intestinal intraepithelial lymphocytes • CD5 • FACS

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