Cell Migration Laboratory, Department of Dermatology, University of Würzburg, Würzburg, Germany
Correspondence: Peter Friedl, Cell Migration Laboratory, Department of Dermatology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. E-mail: peter.fr{at}mail.uni-wuerzburg.de
Cell movement within three-dimensional tissues is a cycling multistep process that requires the integration of complex biochemical and biophysical cell functions. Different cells solve this challenge differently, which leads to differences in migration strategies. Migration principles established for leukocytes share many characteristics with those described for ameba of the lower eukaryote Dictyostelium discoideum. The hallmarks of amoeboid movement include a simple polarized shape, dynamic pseudopod protrusion and retraction, flexible oscillatory shape changes, and rapid low-affinity crawling. Amoeboid crawling includes haptokinetic adhesion-dependent as well as biophysical migration mechanisms on or within many structurally and functionally different substrates. We describe central aspects of amoeboid movement in leukocytes and the implications for leukocyte crawling and positioning strategies within interstitial tissues.
Key Words: T lymphocytes • collagen matrix • cytoskeletal dynamics • migration strategies
This article has been cited by other articles:
 |
|
 |
|
  P. Friedl and K. Wolf Plasticity of cell migration: a multiscale tuning model J. Cell Biol., January 11, 2010; 188(1): 11 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Pflicke and M. Sixt Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels J. Exp. Med., December 21, 2009; 206(13): 2925 - 2935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Fisher, A. Sacharidou, A. N. Stratman, A. M. Mayo, S. B. Fisher, R. D. Mahan, M. J. Davis, and G. E. Davis MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices J. Cell Sci., December 15, 2009; 122(24): 4558 - 4569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Quast, B. Tappertzhofen, C. Schild, J. Grell, N. Czeloth, R. Forster, R. Alon, L. Fraemohs, K. Dreck, C. Weber, et al. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells Blood, June 4, 2009; 113(23): 5801 - 5810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Jacobelli, F. C. Bennett, P. Pandurangi, A. J. Tooley, and M. F. Krummel Myosin-IIA and ICAM-1 Regulate the Interchange between Two Distinct Modes of T Cell Migration J. Immunol., February 15, 2009; 182(4): 2041 - 2050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Jevnikar, N. Obermajer, M. Bogyo, and J. Kos The role of cathepsin X in the migration and invasiveness of T lymphocytes J. Cell Sci., August 15, 2008; 121(16): 2652 - 2661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Beauchemin, N. M. Dixit, and A. S. Perelson Characterizing T Cell Movement within Lymph Nodes in the Absence of Antigen J. Immunol., May 1, 2007; 178(9): 5505 - 5512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mrass, H. Takano, L. G. Ng, S. Daxini, M. O. Lasaro, A. Iparraguirre, L. L. Cavanagh, U. H. von Andrian, H. C.J. Ertl, P. G. Haydon, et al. Random migration precedes stable target cell interactions of tumor-infiltrating T cells J. Exp. Med., November 27, 2006; 203(12): 2749 - 2761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fache, J. Dalous, M. Engelund, C. Hansen, F. Chamaraux, B. Fourcade, M. Satre, P. Devreotes, and F. Bruckert Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility J. Cell Sci., August 1, 2005; 118(15): 3445 - 3458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Holmbeck, P. Bianco, I. Pidoux, S. Inoue, R. C. Billinghurst, W. Wu, K. Chrysovergis, S. Yamada, H. Birkedal-Hansen, and A. R. Poole The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone J. Cell Sci., January 1, 2005; 118(1): 147 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Gebbie, M. Benghezal, S. Cornillon, R. Froquet, N. Cherix, M. Malbouyres, Y. Lefkir, C. Grangeasse, S. Fache, J. Dalous, et al. Phg2, a Kinase Involved in Adhesion and Focal Site Modeling in Dictyostelium Mol. Biol. Cell, August 1, 2004; 15(8): 3915 - 3925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wolf, R. Muller, S. Borgmann, Eva.-B. Brocker, and P. Friedl Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases Blood, November 1, 2003; 102(9): 3262 - 3269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Wolf, I. Mazo, H. Leung, K. Engelke, U. H. von Andrian, E. I. Deryugina, A. Y. Strongin, E.-B. Brocker, and P. Friedl Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis J. Cell Biol., January 21, 2003; 160(2): 267 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Samstag, S. M. Eibert, M. Klemke, and G. H. Wabnitz Actin cytoskeletal dynamics in T lymphocyte activation and migration J. Leukoc. Biol., January 1, 2003; 73(1): 30 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fey, S. Stephens, M. A. Titus, and R. L. Chisholm SadA, a novel adhesion receptor in Dictyostelium J. Cell Biol., December 20, 2002; 159(6): 1109 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Beyer, M. Meyer-Hermann, and G. Soff A possible role of chemotaxis in germinal center formation Int. Immunol., December 1, 2002; 14(12): 1369 - 1381. [Abstract] [Full Text] [PDF]
|
|
