Division of Infectious Diseases, Department of Internal Medicine, The University of Texas Medical Branch, Galveston
Correspondence: Dr. Fujio Suzuki, Department of Internal Medicine, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435. E-mail: fsuzuki{at}utmb.edu
Monocyte chemoattractant protein (MCP)-1 has a pathogenic role in
herpesvirus-induced encephalomyelitis (HSM). Anti-MCP-1 antibody
greatly decreased HSM severity in mice infected with herpes simplex
virus type 2 (HSM mice), compared with its effect in control HSM mice
treated with rabbit immunoglobulin. HSM severity was markedly enhanced
in mice previously treated with a mixture of interleukin (IL) 4 and
-10. In response to stimulation with antigen, HSM mouse cells isolated
from cerebrospinal fluids (CSF cells) produced IL-4 in culture fluids;
however, IL-4 production decreased in CSF cells derived from HSM mice
previously treated with anti-MCP-1 antibody. A macrophage population
isolated in CSF cells from HSM mice (CSF-M
) produced MCP-1 in
culture fluids. In response to stimulation with herpesvirus antigen, a
population of T cells isolated from CSF cells from HSM mice (CSF-T
cells) produced IL-4 into their culture fluids, although MCP-1 was not
produced by CSF-T cells stimulated by this antigen. IL-4 production by
CSF-T cells was markedly enhanced when they were stimulated with viral
antigen in the presence of murine recombinant MCP-1 (rMCP-1).
Furthermore, IL-4 was produced in naive splenic T cells cocultured with
CSF-M. These results indicate that the severity of HSM is influenced
by MCP-1, which stimulates Th2 responses.
Key Words: cerebrospinal fluids • herpes simplex virus type 2 • interleukin 4 • MCP-1
This article has been cited by other articles:
 |
|
 |
|
  B. Zhang, Y. K. Chan, B. Lu, M. S. Diamond, and R. S. Klein CXCR3 Mediates Region-Specific Antiviral T Cell Trafficking within the Central Nervous System during West Nile Virus Encephalitis J. Immunol., February 15, 2008; 180(4): 2641 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Thapa, W. A. Kuziel, and D. J. J. Carr Susceptibility of CCR5-Deficient Mice to Genital Herpes Simplex Virus Type 2 Is Linked to NK Cell Mobilization J. Virol., April 15, 2007; 81(8): 3704 - 3713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Kim, P. P. Sarangi, Y. Lee, S. Deshpande Kaistha, S. Lee, and B. T. Rouse Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation J. Leukoc. Biol., December 1, 2006; 80(6): 1405 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takahashi, Y. Tsuda, M. Kobayashi, D. N. Herndon, and F. Suzuki CCL2 as a trigger of manifestations of compensatory anti-inflammatory response syndrome in mice with severe systemic inflammatory response syndrome J. Leukoc. Biol., April 1, 2006; 79(4): 789 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Tsuda, H. Takahashi, M. Kobayashi, T. Hanafusa, D. N. Herndon, and F. Suzuki CCL2, a product of mice early after systemic inflammatory response syndrome (SIRS), induces alternatively activated macrophages capable of impairing antibacterial resistance of SIRS mice J. Leukoc. Biol., August 1, 2004; 76(2): 368 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Katakura, M. Miyazaki, M. Kobayashi, D. N. Herndon, and F. Suzuki CCL17 and IL-10 as Effectors That Enable Alternatively Activated Macrophages to Inhibit the Generation of Classically Activated Macrophages J. Immunol., February 1, 2004; 172(3): 1407 - 1413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Futagami, T Hiratsuka, A Tatsuguchi, K Suzuki, M Kusunoki, Y Shinji, K Shinoki, T Iizumi, T Akamatsu, H Nishigaki, et al. Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells Gut, September 1, 2003; 52(9): 1257 - 1264. [Abstract] [Full Text]
|
|
