| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Laboratory for Molecular Pharmacology, Department of Pharmacology, Panum Institute,
Department for Infectious Diseases, Rigshospitalet, and
7TM Pharma A/S, Copenhagen, Denmark.
Correspondence: Hans Rudolf Lüttichau, Laboratory for Molecular Pharmacology, Panum Institute 18/6, Blegdamsvej 3, DK-2200 Copenhagen, Denmark. E-mail: hrl{at}molpharm.dk
The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonist, whereas vMIP-II acted as a low-affinity antagonist on the murine CCR8 as well as the human CCR8. MC148 was found to bind and block responses through the human CCR8 with high affinity, but surprisingly MC148 was unable to bind and block responses through the murine CCR8. Because MC148 is the only high-affinity antagonist known to target and be selective for CCR8, MC148 is a valuable tool to decipher the role played by CCR8 in the immune system. This study shows that MC148 could not be used in murine inflammatory models; however, it will be interesting to see whether it can be used in other animal models to delineate the role played by CCR8.
Key Words: vMIP-I • vMIP-II • HHV8 • MCV
This article has been cited by other articles:
|
|
 |
|
  H. K. Wang, U. J. Park, S. Y. Kim, J. H. Lee, S. U. Kim, B. J. Gwag, and Y. B. Lee Free Radical Production in CA1 Neurons Induces MIP-1{alpha} Expression, Microglia Recruitment, and Delayed Neuronal Death after Transient Forebrain Ischemia J. Neurosci., February 13, 2008; 28(7): 1721 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Dewin, J. Catusse, and U. A. Gompels Identification and Characterization of U83A Viral Chemokine, a Broad and Potent {beta}-Chemokine Agonist for Human CCRs with Unique Selectivity and Inhibition by Spliced Isoform J. Immunol., January 1, 2006; 176(1): 544 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lucas and G. McFadden Secreted Immunomodulatory Viral Proteins as Novel Biotherapeutics J. Immunol., October 15, 2004; 173(8): 4765 - 4774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Haque, J. T. Fallon, J. J. Pan, M. B. Taubman, and P. C. Harpel Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion Blood, February 15, 2004; 103(4): 1296 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Najarro, H.-J. Lee, J. Fox, J. Pease, and G. L. Smith Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1 J. Gen. Virol., December 1, 2003; 84(12): 3325 - 3336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lindow, A. Nansen, C. Bartholdy, A. Stryhn, N. J. V. Hansen, T. P. Boesen, T. N. C. Wells, T. W. Schwartz, and A. R. Thomsen The Virus-Encoded Chemokine vMIP-II Inhibits Virus-Induced Tc1-Driven Inflammation J. Virol., July 1, 2003; 77(13): 7393 - 7400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Johnston and G. McFadden Poxvirus Immunomodulatory Strategies: Current Perspectives J. Virol., June 1, 2003; 77(11): 6093 - 6100. [Full Text] [PDF]
|
|
|
|
|
|
W. J. Jabs, H. J. Wagner, S. Maurmann, H. Hennig, and B. Kreft Inhibition of macrophage inflammatory protein-1alpha production by Epstein-Barr virus Blood, March 1, 2002; 99(5): 1512 - 1516. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
