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(Journal of Leukocyte Biology. 2001;70:1-10.)
© 2001 by Society for Leukocyte Biology

The search for new vaccines against tuberculosis

Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado

Correspondence: Ian Orme, Ph.D., Department of Microbiology, Colorado State University, Fort Collins CO 80523. E-mail: iorme{at}lamar.colostate.edu

The failure of the BCG vaccine for tuberculosis in large, controlled clinical trials, coupled with the gradual consensus that it is mostly ineffective in preventing adult pulmonary disease in endemic areas, has led to a concerted effort to develop a new generation of vaccines. This work is ongoing in a variety of areas, including DNA vaccines, subunit vaccines, recombinant vaccines, and auxotrophic vaccines. Several such candidates are giving promising results in mouse and guinea pig, aerosol-challenge infection models and should move to clinical trials in the near future.

Key Words: BCG • animal models • T cells

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