| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Leuven, Belgium
Correspondence: Ghislain Opdenakker, Laboratory of Molecular Immunology, Rega Institute, University of Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. E-mail: ghislain.opdenakker{at}rega.kuleuven.ac.be
Matrix metalloproteinases (MMPs) form a family of enzymes
with major actions in the remodeling of extracellular matrix (ECM)
components. Gelatinase B (MMP-9) is the most complex family member in
terms of domain structure and regulation of its activity. Gelatinase B
activity is under strict control at various levels: transcription of
the gene by cytokines and cellular interactions; activation of the
pro-enzyme by a cascade of enzymes comprising serine proteases and
other MMPs; and regulation by specific tissue inhibitors of MMPs
(TIMPs) or by unspecific inhibitors, such as
2-macroglobulin. Thus, remodeling ECM is the result of
the local protease load, i.e., the net balance between enzymes and
inhibitors. Glycosylation has a limited effect on the net activity of
gelatinase B, and in contrast to the all-or-none effect of
enzyme activation or inhibition, it results in a higher-level,
fine-tuning effect on the ECM catalysis by proteases in mammalian
species. Fast degranulation of considerable amounts of intracellularly
stored gelatinase B from neutrophils, induced by various types of
chemotactic factors, is another level of control of activity.
Neutrophils are first-line defense leukocytes and do not produce
gelatinase A or TIMP. Thus, neutrophils contrast sharply with
mononuclear leukocytes, which produce gelatinase A constitutively,
synthesize gelatinase B de novo after adequate triggering,
and overproduce TIMP-1. Gelatinase B is also endowed with functions
other than cleaving the ECM. It has been shown to generate autoimmune
neo-epitopes and to activate pro-IL-1ß into active IL-1ß.
Gelatinase B ablation in the mouse leads to altered bone remodeling and
subfertility, results in resistance to several induced inflammatory or
autoimmune pathologies, and indicates that the enzyme plays a crucial
role in development and angiogenesis. The major human neutrophil
chemoattractant, IL-8, stimulates fast degranulation of gelatinase B
from neutrophils. Gelatinase B is also found to function as a regulator
of neutrophil biology and to truncate IL-8 at the aminoterminus into a
tenfold more potent chemokine, resulting in an important positive
feedback loop for neutrophil activation and chemotaxis. The CXC
chemokines GRO-, CTAP-III, and PF-4 are degraded by gelatinase B,
whereas the CC chemokines MCP-2 and RANTES are not cleaved.
Key Words: matrix metalloproteinases • extracellular matrix • TIMP • neutrophils
Related Article
J. Leukoc. Biol. 2007 81: 369-371.
This article has been cited by other articles:
|
|
 |
|
  P. Welsh, P.H. Whincup, O. Papacosta, S.G. Wannamethee, L. Lennon, A. Thomson, A. Rumley, and G.D.O. Lowe Serum matrix metalloproteinase-9 and coronary heart disease: a prospective study in middle-aged men QJM, October 1, 2008; 101(10): 785 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Goda, H. Inoue, Y. Kaneshita, Y. Nagano, Y. T. Ikeo, J. Iida, and N. Domae Emdogain Stimulates Matrix Degradation by Osteoblasts J. Dent. Res., August 1, 2008; 87(8): 782 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Goda, H. Inoue, Y. Kaneshita, Y. Nagano, Y. T. Ikeo, J. Iida, and N. Domae Emdogain Stimulates Matrix Degradation by Osteoblasts Journal of Dental Research, August 1, 2008; 87(8): 782 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cuadrado, L. Ortega, M. Hernandez-Guillamon, A. Penalba, I. Fernandez-Cadenas, A. Rosell, and J. Montaner Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release J. Leukoc. Biol., July 1, 2008; 84(1): 207 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mannello Serum or Plasma Samples?: The "Cinderella" Role of Blood Collection Procedures Preanalytical Methodological Issues Influence the Release and Activity of Circulating Matrix Metalloproteinases and Their Tissue Inhibitors, Hampering Diagnostic Trueness and Leading to Misinterpretation Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 611 - 614. [Full Text] [PDF]
|
|
|
|
 |
|
 V. C. Ardi, T. A. Kupriyanova, E. I. Deryugina, and J. P. Quigley Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis PNAS, December 18, 2007; 104(51): 20262 - 20267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aharinejad, K. Krenn, A. Zuckermann, R. Schafer, P. Paulus, G. Seebacher, E. Wolner, and M. Grimm Matrix metalloproteases and their tissue inhibitor in cardiac transplantation Eur. J. Cardiothorac. Surg., July 1, 2007; 32(1): 48 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mannello, G.A.M. Tonti, and F. Canestrari The `never-ending story' of the influence of blood specimen collection methods affecting the concentration, the zymographic profile and the usefulness of matrix metalloproteinases and their tissue inhibitors in multiple sclerosis diagnosis/prognosis: a landmark for limiting the misuse of serum samples Multiple Sclerosis, June 1, 2007; 13(5): 687 - 690. [PDF]
|
|
|
|
|
|
B. Marom, M. A. Rahat, N. Lahat, L. Weiss-Cerem, A. Kinarty, and H. Bitterman Native and fragmented fibronectin oppositely modulate monocyte secretion of MMP-9 J. Leukoc. Biol., June 1, 2007; 81(6): 1466 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Malik, C. S. Bakshi, K. McCabe, S. V. Catlett, A. Shah, R. Singh, P. L. Jackson, A. Gaggar, D. W. Metzger, J. A. Melendez, et al. Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis J. Immunol., January 15, 2007; 178(2): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Taylor, J. M. Hattle, S. A. Dreitz, J. M. Troudt, L. S. Izzo, R. J. Basaraba, I. M. Orme, L. M. Matrisian, and A. A. Izzo Role for Matrix Metalloproteinase 9 in Granuloma Formation during Pulmonary Mycobacterium tuberculosis Infection Infect. Immun., November 1, 2006; 74(11): 6135 - 6144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xue, M. D. Hollenberg, and V. Wee Yong Combination of Thrombin and Matrix Metalloproteinase-9 Exacerbates Neurotoxicity in Cell Culture and Intracerebral Hemorrhage in Mice J. Neurosci., October 4, 2006; 26(40): 10281 - 10291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Imtiaz, J. H. Schripsema, I. M. Sigar, J. N. Kasimos, and K. H. Ramsey Inhibition of Matrix Metalloproteinases Protects Mice from Ascending Infection and Chronic Disease Manifestations Resulting from Urogenital Chlamydia muridarum Infection. Infect. Immun., October 1, 2006; 74(10): 5513 - 5521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Lockwood, F. Arcuri, P. Toti, C. D. Felice, G. Krikun, S. Guller, L. F. Buchwalder, and F. Schatz Tumor Necrosis Factor-{alpha} and Interleukin-1{beta} Regulate Interleukin-8 Expression in Third Trimester Decidual Cells: Implications for the Genesis of Chorioamnionitis Am. J. Pathol., October 1, 2006; 169(4): 1294 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Kim, M. H. Suk, D. W. Yoon, S. H. Lee, G. Y. Hur, K. H. Jung, H. C. Jeong, S. Y. Lee, S. Y. Lee, I. B. Suh, et al. Inhibition of matrix metalloproteinase-9 prevents neutrophilic inflammation in ventilator-induced lung injury Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L580 - L587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ernens, D. Rouy, E. Velot, Y. Devaux, and D. R. Wagner Adenosine Inhibits Matrix Metalloproteinase-9 Secretion By Neutrophils: Implication of A2a Receptor and cAMP/PKA/Ca2+ Pathway Circ. Res., September 15, 2006; 99(6): 590 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Melamed, O. Messika, L. Glass-Marmor, and A. Miller Modulation of matrix metalloproteinase-9 (MMP-9) secretion in B lymphopoiesis Int. Immunol., September 1, 2006; 18(9): 1355 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kolaczkowska, A. Scislowska-Czarnecka, M. Chadzinska, B. Plytycz, N. van Rooijen, G. Opdenakker, and B. Arnold Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin J. Leukoc. Biol., July 1, 2006; 80(1): 125 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ning, K. L. Furie, W. J. Koroshetz, H. Lee, M. Barron, M. Lederer, X. Wang, M. Zhu, A. G. Sorensen, E. H. Lo, et al. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke Neurology, May 23, 2006; 66(10): 1550 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Medina, A. Santana, M. C. Paz, F. Diaz-Gonzalez, E. Farre, A. Salas, M. W. Radomski, and E. Quintero Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis J. Leukoc. Biol., May 1, 2006; 79(5): 954 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Rahat, B. Marom, H. Bitterman, L. Weiss-Cerem, A. Kinarty, and N. Lahat Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association J. Leukoc. Biol., April 1, 2006; 79(4): 706 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chabot, P. Reverdiau, S. Iochmann, A. Rico, D. Senecal, C. Goupille, P.-Y. Sizaret, and L. Sensebe CCL5-enhanced human immature dendritic cell migration through the basement membrane in vitro depends on matrix metalloproteinase-9 J. Leukoc. Biol., April 1, 2006; 79(4): 767 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Vanhoutte, M. Schellings, Y. Pinto, and S. Heymans Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window Cardiovasc Res, February 15, 2006; 69(3): 604 - 613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. McClellan, X. Huang, R. P. Barrett, S. Lighvani, Y. Zhang, D. Richiert, and L. D. Hazlett Matrix Metalloproteinase-9 Amplifies the Immune Response to Pseudomonas aeruginosa Corneal Infection Invest. Ophthalmol. Vis. Sci., January 1, 2006; 47(1): 256 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chakrabarti, J. M. Zee, and K. D. Patel Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release J. Leukoc. Biol., January 1, 2006; 79(1): 214 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zijlstra, M. Seandel, T. A. Kupriyanova, J. J. Partridge, M. A. Madsen, E. A. Hahn-Dantona, J. P. Quigley, and E. I. Deryugina Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells Blood, January 1, 2006; 107(1): 317 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.H. Ramsey, I.M. Sigar, J. H. Schripsema, N. Shaba, and K. P. Cohoon Expression of Matrix Metalloproteinases Subsequent to Urogenital Chlamydia muridarum Infection of Mice Infect. Immun., October 1, 2005; 73(10): 6962 - 6973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-H. Wu, Y. Shoji, M.-C. Wu, P.-C. Chuang, C.-C. Lin, M.-F. Huang, and S.-J. Tsai Suppression of Matrix Metalloproteinase-9 by Prostaglandin E2 in Peritoneal Macrophage Is Associated with Severity of Endometriosis Am. J. Pathol., October 1, 2005; 167(4): 1061 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hirano, B. Y. Ma, N. Kawasaki, K. Okimura, M. Baba, T. Nakagawa, K. Miwa, N. Kawasaki, S. Oka, and T. Kawasaki Mannan-Binding Protein Blocks the Activation of Metalloproteases Meprin {alpha} and {beta} J. Immunol., September 1, 2005; 175(5): 3177 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Gidday, Y. G. Gasche, J.-C. Copin, A. R. Shah, R. S. Perez, S. D. Shapiro, P. H. Chan, and T. S. Park Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H558 - H568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chakrabarti and K. D. Patel Regulation of matrix metalloproteinase-9 release from IL-8-stimulated human neutrophils J. Leukoc. Biol., July 1, 2005; 78(1): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Vosseler, N. Mirancea, P. Bohlen, M. M. Mueller, and N. E. Fusenig Angiogenesis Inhibition by Vascular Endothelial Growth Factor Receptor-2 Blockade Reduces Stromal Matrix Metalloproteinase Expression, Normalizes Stromal Tissue, and Reverts Epithelial Tumor Phenotype in Surface Heterotransplants Cancer Res., February 15, 2005; 65(4): 1294 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hulkkonen, M. Pertovaara, J. Antonen, A. Pasternack, M. Hurme, P. Pollanen, and T. Lehtimaki Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome Rheumatology, December 1, 2004; 43(12): 1476 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Starr, T. Dan, K. Minhas, P. E. Shewen, and B. L. Coomber Potential Involvement of Gelatinases and Their Inhibitors in Mannheimia haemolytica Pneumonia in Cattle Infect. Immun., August 1, 2004; 72(8): 4393 - 4400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Baluk, W. W. Raymond, E. Ator, L. M. Coussens, D. M. McDonald, and G. H. Caughey Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling Am J Physiol Lung Cell Mol Physiol, August 1, 2004; 287(2): L307 - L317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Kim, S. Y. Lee, S. M. Bak, I. B. Suh, S. Y. Lee, C. Shin, J. J. Shim, K. H. In, K. H. Kang, and S. H. Yoo Effects of matrix metalloproteinase inhibitor on LPS-induced goblet cell metaplasia Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L127 - L133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-s. Choi, D. J. Grab, and J. S. Dumler Anaplasma phagocytophilum Infection Induces Protracted Neutrophil Degranulation Infect. Immun., June 1, 2004; 72(6): 3680 - 3683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Rosario, S. W. Waldo, S. A. Becker, and G. W. Schmid-Schonbein Pancreatic Trypsin Increases Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion in the Rat Am. J. Pathol., May 1, 2004; 164(5): 1707 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Maier, L. Hsieh, F. Yu, P. Bracci, and P. H. Chan Matrix Metalloproteinase-9 and Myeloperoxidase Expression: Quantitative Analysis by Antigen Immunohistochemistry in a Model of Transient Focal Cerebral Ischemia Stroke, May 1, 2004; 35(5): 1169 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Crisman, B. Zhang, L. P. Norman, and J. S. Bond Deletion of the Mouse Meprin {beta} Metalloprotease Gene Diminishes the Ability of Leukocytes to Disseminate through Extracellular Matrix J. Immunol., April 1, 2004; 172(7): 4510 - 4519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. F. Nolan, V. Strong, D. Soler, P. J. Fairchild, S. P. Cobbold, R. Croxton, J.-A. Gonzalo, A. Rubio, M. Wells, and H. Waldmann IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals J. Immunol., February 15, 2004; 172(4): 2201 - 2209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakamura, S. Esnault, T. Maeda, E. A. B. Kelly, J. S. Malter, and N. N. Jarjour Ets-1 Regulates TNF-{alpha}-Induced Matrix Metalloproteinase-9 and Tenascin Expression in Primary Bronchial Fibroblasts J. Immunol., February 1, 2004; 172(3): 1945 - 1952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chromek, K. Tullus, J. Lundahl, and A. Brauner Tissue Inhibitor of Metalloproteinase 1 Activates Normal Human Granulocytes, Protects Them from Apoptosis, and Blocks Their Transmigration during Inflammation Infect. Immun., January 1, 2004; 72(1): 82 - 88. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Owen, Z. Hu, B. Barrick, and S. D. Shapiro Inducible Expression of Tissue Inhibitor of Metalloproteinases-Resistant Matrix Metalloproteinase-9 on the Cell Surface of Neutrophils Am. J. Respir. Cell Mol. Biol., September 1, 2003; 29(3): 283 - 294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Y. Vermaelen, D. Cataldo, K. Tournoy, T. Maes, A. Dhulst, R. Louis, J.-M. Foidart, A. Noel, and R. Pauwels Matrix Metalloproteinase-9-Mediated Dendritic Cell Recruitment into the Airways Is a Critical Step in a Mouse Model of Asthma J. Immunol., July 15, 2003; 171(2): 1016 - 1022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Leonardi, P. Brun, G. Abatangelo, M. Plebani, and A. G. Secchi Tear Levels and Activity of Matrix Metalloproteinase (MMP)-1 and MMP-9 in Vernal Keratoconjunctivitis Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3052 - 3058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wolf, I. Clark-Lewis, C. Buri, H. Langen, M. Lis, and L. Mazzucchelli Cathepsin D Specifically Cleaves the Chemokines Macrophage Inflammatory Protein-1{alpha}, Macrophage Inflammatory Protein-1{beta}, and SLC That Are Expressed in Human Breast Cancer Am. J. Pathol., April 1, 2003; 162(4): 1183 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Blankenberg, H. J. Rupprecht, O. Poirier, C. Bickel, M. Smieja, G. Hafner, J. Meyer, F. Cambien, L. Tiret, and for the AtheroGene Investigators Plasma Concentrations and Genetic Variation of Matrix Metalloproteinase 9 and Prognosis of Patients With Cardiovascular Disease Circulation, April 1, 2003; 107(12): 1579 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhou, S. A. Stohlman, D. R. Hinton, and N. W. Marten Neutrophils Promote Mononuclear Cell Infiltration During Viral-Induced Encephalitis J. Immunol., March 15, 2003; 170(6): 3331 - 3336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Miller, R. M. Strieter, A. D. Gruber, S. B. Ho, and N. W. Lukacs CXCR2 Regulates Respiratory Syncytial Virus-Induced Airway Hyperreactivity and Mucus Overproduction J. Immunol., March 15, 2003; 170(6): 3348 - 3356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Hartog, J. A. Wermelt, C. O. Sommerfeld, W. Eichler, K. Dalhoff, and J. Braun Pulmonary Matrix Metalloproteinase Excess in Hospital-acquired Pneumonia Am. J. Respir. Crit. Care Med., February 15, 2003; 167(4): 593 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sanceau, D. D. Boyd, M. Seiki, and B. Bauvois Interferons Inhibit Tumor Necrosis Factor-alpha -mediated Matrix Metalloproteinase-9 Activation via Interferon Regulatory Factor-1 Binding Competition with NF-kappa B J. Biol. Chem., September 13, 2002; 277(38): 35766 - 35775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Cataldo, K. G. Tournoy, K. Vermaelen, C. Munaut, J.-M. Foidart, R. Louis, A. Noel, and R. A. Pauwels Matrix Metalloproteinase-9 Deficiency Impairs Cellular Infiltration and Bronchial Hyperresponsiveness during Allergen-Induced Airway Inflammation Am. J. Pathol., August 1, 2002; 161(2): 491 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Winkler and J. L. Fowlkes Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis? Am J Physiol Lung Cell Mol Physiol, July 1, 2002; 283(1): L1 - L11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhou, S. A. Stohlman, R. Atkinson, D. R. Hinton, and N. W. Marten Matrix Metalloproteinase Expression Correlates with Virulence following Neurotropic Mouse Hepatitis Virus Infection J. Virol., June 27, 2002; 76(15): 7374 - 7384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Moffatt, K. L. Jeffrey, and T. M. Cocks Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 680 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. D. Marchenko, G. N. Marchenko, and A. Y. Strongin Unconventional Activation Mechanisms of MMP-26, a Human Matrix Metalloproteinase with a Unique PHCGXXD Cysteine-switch Motif J. Biol. Chem., May 17, 2002; 277(21): 18967 - 18972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Metayer, F. Dacheux, J.-L. Dacheux, and J.-L. Gatti Comparison, Characterization, and Identification of Proteases and Protease Inhibitors in Epididymal Fluids of Domestic Mammals. Matrix Metalloproteinases Are Major Fluid Gelatinases Biol Reprod, May 1, 20 |
