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(Journal of Leukocyte Biology. 2001;69:555-564.)
© 2001 by Society for Leukocyte Biology

Expression and function of galectin-3, a ß-galactoside-binding protein in activated T lymphocytes

Hong-Gu Joo, Peter S Goedegebuure, Noriaki Sadanaga, Makoto Nagoshi, Wolfram von Bernstorff and Timothy J. Eberlein

Laboratory of Biologic Cancer Therapy, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri

Correspondence: Dr. Peter S. Goedegebuure, Department of Surgery, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110. E-mail: goedegep{at}msnotes.wustl.edu

A soluble beta-galactoside-binding lectin, galectin-3 has been shown to be involved in cell adhesion and activation of immune cells. Although galectin-3 is known to be expressed in various types of cells, it has not been shown whether galectin-3 is expressed in T lymphocytes. We present evidence here that galectin-3 is expressed in activated murine T lymphocytes including CD4+ and CD8+ T cells but not in resting T cells. Galectin-3 expression was induced by anti-CD3 mAb or mitogen and enhanced by common {gamma}-chain signaling cytokines, IL-2, IL-4, and IL-7, in activated T lymphocytes, whereas the inflammatory cytokines including TNF-{alpha} and IFN-{gamma} did not. Galectin-3 expression and proliferation were down-regulated by withdrawal of IL-2 and gamma irradiation. Anti-sense but not sense phosphorothioated oligonucleotides for galectin-3 inhibited galectin-3 expression and blocked proliferation of T cells significantly. This study suggests that up-regulation of galectin-3 plays an important role in proliferation of activated T lymphocytes.

Key Words: common {gamma}-chain signaling cytokines • proliferation • anti-sense




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