Department of Immunology, Parasitology and Ultrastructure, Flemish Interuniversity Institute for Biotechnology, Free University Brussels (VUB), Paardenstraat 65, B-1640 St-Genesius-Rode, Belgium
Correspondence: Dr. Alain Beschin, Cellular Immunology Unit, Flemish Interuniversity Institute for Biotechnology, VIB-VUB, Paardenstraat 65, B-1640 St-Genesius-Rode, Belgium. E-mail: abeschin{at}vub.ac.be
The type I/type II cytokine balance may influence the development of
different subsets of suppressive macrophages, i.e., classically
activated macrophages (caM
, type I) versus alternatively activated
macrophages (aaM, type II). Recently, we showed that although mice
infected with phospholipase C-deficient
(PLC-/-) Trypanosoma brucei
brucei exhibit a clear shift from type I to the type II cytokine
production, wild type (WT)-infected mice remain locked in a type I
cytokine response. In the present study, phenotype and accessory cell
function of macrophages elicited during WT and
PLC-/- T. b. brucei infection
were compared. Results indicate that caM develop in a type I
cytokine environment in the early phase of WT and
PLC-/- trypanosome infection, correlating
with inhibition of T cell activation triggered by a mitogen, a
superantigen, or an antigen. In the late stage of infection, only
PLC-/--infected mice resisting the infection
develop type II cytokine-associated aaM correlating with impaired
antigen- but not mitogen- or superantigen-induced T cell
activation.
Key Words: antigen presentation • immunosuppression • phospholipase C • trypanosome infection
This article has been cited by other articles:
 |
|
 |
|
  M. Guilliams, K. Movahedi, T. Bosschaerts, T. VandenDriessche, M. K. Chuah, M. Herin, A. Acosta-Sanchez, L. Ma, M. Moser, J. A. Van Ginderachter, et al. IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection J. Immunol., January 15, 2009; 182(2): 1107 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lopez, K. P. Demick, J. M. Mansfield, and D. M. Paulnock Type I IFNs Play a Role in Early Resistance, but Subsequent Susceptibility, to the African Trypanosomes J. Immunol., October 1, 2008; 181(7): 4908 - 4917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Gangadharan, M. A. Hoeve, J. E. Allen, B. Ebrahimi, S. M. Rhind, B. M. Dutia, and A. A. Nash Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages J. Leukoc. Biol., July 1, 2008; 84(1): 50 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Stijlemans, T. N. Baral, M. Guilliams, L. Brys, J. Korf, M. Drennan, J. Van Den Abbeele, P. De Baetselier, and S. Magez A Glycosylphosphatidylinositol-Based Treatment Alleviates Trypanosomiasis-Associated Immunopathology J. Immunol., September 15, 2007; 179(6): 4003 - 4014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guilliams, G. Oldenhove, W. Noel, M. Herin, L. Brys, P. Loi, V. Flamand, M. Moser, P. De Baetselier, and A. Beschin African Trypanosomiasis: Naturally Occurring Regulatory T Cells Favor Trypanotolerance by Limiting Pathology Associated with Sustained Type 1 Inflammation J. Immunol., September 1, 2007; 179(5): 2748 - 2757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Namangala, C. Sugimoto, and N. Inoue Effects of Exogenous Transforming Growth Factor {beta} on Trypanosoma congolense Infection in Mice Infect. Immun., April 1, 2007; 75(4): 1878 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hassanzadeh Ghassabeh, P. De Baetselier, L. Brys, W. Noel, J. A. Van Ginderachter, S. Meerschaut, A. Beschin, F. Brombacher, and G. Raes Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions Blood, July 15, 2006; 108(2): 575 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Raes, L. Brys, B. K. Dahal, J. Brandt, J. Grooten, F. Brombacher, G. Vanham, W. Noel, P. Bogaert, T. Boonefaes, et al. Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation J. Leukoc. Biol., March 1, 2005; 77(3): 321 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Manca, M. B. Reed, S. Freeman, B. Mathema, B. Kreiswirth, C. E. Barry III, and G. Kaplan Differential Monocyte Activation Underlies Strain-Specific Mycobacterium tuberculosis Pathogenesis Infect. Immun., September 1, 2004; 72(9): 5511 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Gavrilescu, B. A. Butcher, L. Del Rio, G. A. Taylor, and E. Y. Denkers STAT1 Is Essential for Antimicrobial Effector Function but Dispensable for Gamma Interferon Production during Toxoplasma gondii Infection Infect. Immun., March 1, 2004; 72(3): 1257 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Geldhof, J. A. Van Ginderachter, Y. Liu, W. Noel, G. Raes, and P. De Baetselier Antagonistic effect of NK cells on alternatively activated monocytes: a contribution of NK cells to CTL generation Blood, December 1, 2002; 100(12): 4049 - 4058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Noel, G. Hassanzadeh, G. Raes, B. Namangala, I. Daems, L. Brys, F. Brombacher, P. D. Baetselier, and A. Beschin Infection Stage-Dependent Modulation of Macrophage Activation in Trypanosoma congolense-Resistant and -Susceptible Mice Infect. Immun., November 1, 2002; 70(11): 6180 - 6187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stempin, L. Giordanengo, S. Gea, and F. Cerban Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain, a parasite antigen J. Leukoc. Biol., October 1, 2002; 72(4): 727 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Motran, F. L. Diaz, A. Gruppi, D. Slavin, B. Chatton, and J. L. Bocco Human pregnancy-specific glycoprotein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell-dependent T cell proliferation J. Leukoc. Biol., September 1, 2002; 72(3): 512 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Raes, P. De Baetselier, W. Noel, A. Beschin, F. Brombacher, and G. Hassanzadeh Gh. Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages J. Leukoc. Biol., April 1, 2002; 71(4): 597 - 602. [Abstract] [Full Text] [PDF]
|
|
