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(Journal of Leukocyte Biology. 2001;69:317-330.)
© 2001 by Society for Leukocyte Biology

Molecular motors involved in T cell receptor clusterings

Connie Krawczyk and Josef M. Penninger

Amgen Institute/Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, University of Toronto, Ontario, Canada

Correspondence: Josef Penninger, Amgen Institute/Ontario Cancer Institute, Departments of Medical Biophysics and Immunology, University of Toronto, 620 Toronto Ave., Ontario, Canada M5G 2C1. E-mail: jpenning{at}amgen.com

Engagement of antigen receptors on T and B cells triggers reorganization of the cytoskeleton and ordered clustering of cell surface receptors. These receptor clusters constitute spatially organized signaling machines and form the immune synapse with antigen-presenting cells. Formation of supramolecular activation clusters appear to be essential to induce functional lymphocyte responses and have been implicated as molecular mechanisms of costimulation. The Vav1-Rho-GTPase-WASP pathway constitutes a molecular motor that relays antigen receptor stimulation to changes in the cytoskeleton and receptor clustering.

Key Words: lymphocytes • actin • Vav • cytoskeleton • T-cell activation • immune synapse




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