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Department of Physiology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China
Correspondence: Dr. Chauying J. Jen, Department of Physiology, College of Medicine, National Cheng-Kung University, Tainan 701, Taiwan, Republic of China. E-mail: jen{at}mail.ncku.edu.tw
Because physical activity affects the immune competency of individuals
by an unknown mechanism, we investigated the effect of acute exercise
on phagocytosis of bronchoalveolar macrophages (BAMs). Male BALB/c
mice, 7–9 weeks old, ran on a treadmill to exhaustion (severe
exercise, SE) or at a final speed of 17 m/min for 30 min (moderate
exercise, ME). Although both exercise protocols induced differential
leukocytosis, 95% leukocytes from lung lavages of both groups were
BAMs. The BAM phagocytic capacity of nonopsonized beads increased
immediately after SE but not after ME, gradually returning to the basal
level after 4 h. SE upregulates the macrophage scavenger receptors
(SR-A type I/II and MARCO), CR3, and ICAM-1, but not Fc
R. Although
the blocking effect of MARCO antibody was most pronounced, that of
ICAM-1 antibody was totally reversed by cross-linking CR3. Our results
showed that SE, but not ME, activated BAMs and that the enhanced
nonopsonized phagocytosis was mainly mediated by scavenger receptors
and ICAM-1/CR3.
Key Words: scavenger receptor • CR3 • ICAM-1
This article has been cited by other articles:
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  S.-H. Su, H.-i. Chen, and C. J. Jen C57BL/6 and BALB/c Bronchoalveolar Macrophages Respond Differently to Exercise J. Immunol., November 1, 2001; 167(9): 5084 - 5091. [Abstract] [Full Text] [PDF]
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