science pharmaceutical expo biotech jobs

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmad, R.
Right arrow Articles by Ahmad, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ahmad, R.
Right arrow Articles by Ahmad, A.
(Journal of Leukocyte Biology. 2001;69:123-128.)
© 2001 by Society for Leukocyte Biology

Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells

Rasheed Ahmad, José Menezes, Laurent Knafo and Ali Ahmad

Laboratory of Immunovirology, Department of Microbiology & Immunology, University of Montreal and Sainte-Justine Hospital Research Center, Montreal, Quebec, Canada

Correspondence: Ali Ahmad, D.V.M., Ph.D., Research Center, Hôpital Sainte-Justine, 3175 Côte Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. E-mail: ahmada{at}justine.umontreal.ca

In addition to their role in hemostasis and thrombosis, platelets are important modulators of immune and inflammatory responses. We provide evidence here that human platelets contain abundant quantities of Fas-L, and upon activation, they express it on their surface as well as release it into medium. This surface-expressed Fas-L is biologically active and can induce apoptosis in Fas-positive human tumor cells. Therefore, activated platelets may represent an important player in Fas/Fas-L-mediated apoptosis.

Key Words: platelets • thrombocytes • Fas-L • apoptosis • tumor cells




This article has been cited by other articles:


Home page
 Arch NeurolHome page
L. M. Wachtman, R. L. Skolasky, P. M. Tarwater, D. Esposito, G. Schifitto, K. Marder, M. P. McDermott, B. A. Cohen, A. Nath, N. Sacktor, et al.
Platelet Decline: An Avenue for Investigation Into the Pathogenesis of Human Immunodeficiency Virus Associated Dementia
Arch Neurol, September 1, 2007; 64(9): 1264 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Otterdal, C. Smith, E. Oie, T. M. Pedersen, A. Yndestad, E. Stang, K. Endresen, N. O. Solum, P. Aukrust, and J. K. Damas
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes
Blood, August 1, 2006; 108(3): 928 - 935.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
B. D. Elzey, J. F. Grant, H. W. Sinn, B. Nieswandt, T. J. Waldschmidt, and T. L. Ratliff
Cooperation between platelet-derived CD154 and CD4+ T cells for enhanced germinal center formation
J. Leukoc. Biol., July 1, 2005; 78(1): 80 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. H. Albertine, M. F. Soulier, Z. Wang, A. Ishizaka, S. Hashimoto, G. A. Zimmerman, M. A. Matthay, and L. B. Ware
Fas and Fas Ligand Are Up-Regulated in Pulmonary Edema Fluid and Lung Tissue of Patients with Acute Lung Injury and the Acute Respiratory Distress Syndrome
Am. J. Pathol., November 1, 2002; 161(5): 1783 - 1796.
[Abstract] [Full Text] [PDF]