Departments of
* Immunology and
Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York
Correspondence: Dr. Elizabeth Repasky, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263. E-mail: Elizabeth.Repasky{at}RoswellPark.org
The thermal component of fever is one of the most poorly understood
aspects of inflammation. To evaluate the role of fever-range
hyperthermia on acute inflammation, BALB/c and C57BL/6 mice were
exposed to mild, long-duration whole-body hyperthermia (WBH), and serum
concentrations of tumor necrosis factor 
(TNF-), interleukin-6
(IL-6), IL-1ß, and the acute phase proteins (APPs) 1-acid
glycoprotein and haptoglobin were analyzed. WBH alone did not affect
serum concentrations of these cytokines or APPs when compared with
controls. In contrast, when WBH was applied just after intraperitoneal
administration of lipopolysaccharide (LPS), serum concentrations of
TNF- and IL-6 were greater than or equal to threefold higher in
BALB/c mice compared with LPS-treated controls. LPS-induced IL-6 levels
were also enhanced in WBH-treated C57BL/6 mice. However, APP levels
were prolonged only in WBH-treated BALB/c mice. It is interesting that
in vitro hyperthermia treatment of LPS-stimulated
peritoneal cells resulted in decreased cytokine production compared
with controls. These results suggest that fever-range hyperthermia
regulates acute inflammation in a mouse strain-specific manner that is
more complex than that observed in vitro.
Key Words: acute phase reactants • cytokines • immunomodulators
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