Journal of Leukocyte Biology eBioscience full spectrum cell analysis
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Böckmann, S.
Right arrow Articles by Paegelow, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Böckmann, S.
Right arrow Articles by Paegelow, I.
(Journal of Leukocyte Biology. 2000;68:587-592.)
© 2000 by Society for Leukocyte Biology

Kinins and kinin receptors: importance for the activation of leukocytes

Sabine Böckmann and Inge Paegelow

Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Rostock, Germany

Correspondence: Sabine Böckmann, Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty, University of Rostock, Schillingallee 70, 18055 Rostock, Germany. E-mail: pharma-toxi{at}med.uni-rostock.de

In this article, we analyzed the role of kinins and kinin receptors with respect to the activation of leukocytes. In these cells, the biological effects of kinin peptides are mediated by kinin receptor subtypes B1, B2, or both, depending on species and cell type. In contrast to the other leukocytes, neutrophils contain the complete system for the synthesis and release of bioactive kinins. Consequently, very high concentrations of these peptides can be reached in the close neighborhood of the kinin receptors, in particular at the site of inflammation. Kinins are responsible for many effects in leukocytes including the release of other inflammatory mediators, such as cytokines, prostaglandins, leukotrienes, and reactive oxygen species. Obviously, the potency of kinins to stimulate leukocytes is dependent on the differentiation and especially on the activation stage of these cells. An upregulation of kinin receptors on neutrophils and macrophages appears to be involved in increasing the sensitivity of these cells to kinins at the site of inflammation.

Key Words: kinins • inflammatory cells • G protein-coupled receptor • signal transduction




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
C. M. Bertram, S. Baltic, N. L. Misso, K. D. Bhoola, P. S. Foster, P. J. Thompson, and M. Fogel-Petrovic
Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration
J. Leukoc. Biol., June 1, 2007; 81(6): 1445 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. M. F. Leeb-Lundberg, F. Marceau, W. Muller-Esterl, D. J. Pettibone, and B. L. Zuraw
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences
Pharmacol. Rev., March 1, 2005; 57(1): 27 - 77.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Stuardo, C. B. Gonzalez, F. Nualart, M. Boric, J. Corthorn, K. D. Bhoola, and C. D. Figueroa
Stimulated human neutrophils form biologically active kinin peptides from high and low molecular weight kininogens
J. Leukoc. Biol., April 1, 2004; 75(4): 631 - 640.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Society for Leukocyte Biology.