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Faculty of Biosciences, Pharmaceutics and Psychology, University of Leipzig, Talstrasse 33, D-04103 Leipzig, Germany
Correspondence and present address: Dr. W. Eichler, University of Leipzig, Interdisciplinary Centre for Clinical Research, Department of Ophthalmology, Liebigstrasse 10-14, D-04103 Leipzig, Germany
Different adhesive capacity in interactions with CD55 has been ascribed
to the isoforms of the leukocyte CD97 antigen, CD97 (EGF 1,2,5), CD97
(EGF 1,2,3,5), and CD97 (EGF 1,2,3,4,5). In the study, coexpression of
the three CD97 isoforms and predominance of CD97 (EGF 1,2,5)
transcripts in leukocytes are demonstrated. The contribution of CD97
(EGF 1,2,3,5) and CD97 (EGF 1,2,3,4,5) to total CD97 levels varied
among most cell types only slightly, although relatively higher mRNA
levels of both isoforms were detected in U 937 cells and monocytes. In
peripheral blood lymphocytes, CD97 isoforms did not show clear
variation after PMA stimulation and were down-regulated equally after
CD97 cross-linking. Moreover, the CD97 isoform pattern was not altered
in monocytes after interferon-
stimulation and in synovial T cells
from patients with rheumatoid arthritis. CD97 mRNA levels did not
necessarily correspond to CD97 surface density. The findings suggest
that adhesive activity of CD97 toward CD55 is unlikely to be regulated
by differential CD97 isoform expression.
Key Words: leukocytes • CD97 isoforms • EGF-like domains • CD55
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