* Department of Medicine, University of Colorado Health Sciences Center, Denver; and
Metabolism Section, Department of Veterans Affairs Medical Center, University of California, San Francisco
Correspondence: Giamila Fantuzzi, Ph.D., Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262. E-mail: Giamila.Fantuzzi{at}UCHSC.edu
Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are present in leptin- or leptin-receptor-deficient animals, as well as during starvation and malnutrition, two conditions characterized by low levels of circulating leptin. Both leptin and its receptor share structural and functional similarities with the interleukin-6 family of cytokines. Leptin exerts proliferative and anti-apoptotic activities in a variety of cell types, including T lymphocytes, leukemia cells, and hematopoietic progenitors. Leptin also affects cytokine production, the activation of monocytes/macrophages, wound healing, angiogenesis, and hematopoiesis. Moreover, leptin production is acutely increased during infection and inflammation. This review focuses on the role of leptin in the modulation of the innate immune response, inflammation, and hematopoiesis.
Key Words: lymphocytes • cytokines • angiogenesis • metabolism • endocrinology
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R. A. French, S. R. Broussard, W. A. Meier, C. Minshall, S. Arkins, J. F. Zachary, R. Dantzer, and K. W. Kelley Age-Associated Loss of Bone Marrow Hematopoietic Cells Is Reversed by GH and Accompanies Thymic Reconstitution Endocrinology, February 1, 2002; 143(2): 690 - 699. [Abstract] [Full Text] [PDF]
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N. Busso, A. So, V. Chobaz-Peclat, C. Morard, E. Martinez-Soria, D. Talabot-Ayer, and C. Gabay Leptin Signaling Deficiency Impairs Humoral and Cellular Immune Responses and Attenuates Experimental Arthritis J. Immunol., January 15, 2002; 168(2): 875 - 882. [Abstract] [Full Text] [PDF]
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C. Gabay, M. G. Dreyer, N. Pellegrinelli, R. Chicheportiche, and C. A. Meier Leptin Directly Induces the Secretion of Interleukin 1 Receptor Antagonist in Human Monocytes J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 783 - 791. [Abstract] [Full Text]
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 F. Parhami, Y. Tintut, A. Ballard, A. M. Fogelman, and L. L. Demer Leptin Enhances the Calcification of Vascular Cells : Artery Wall as a Target of Leptin Circ. Res., May 11, 2001; 88(9): 954 - 960. [Abstract] [Full Text] [PDF]
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