| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Wistar Institute, Philadelphia, Pennsylvania
Correspondence: Dr. L. J. Montaner, Director HIV-1 Immunopathogenesis Lab, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104. E-mail: montaner{at}wistar.upenn.edu
HIV-1 infection elicits a broad range of host responses, many of which
interfere with the regulatory pathways of gene expression of
interleukin-12 (IL-12), a heterodimeric cytokine essential for
cell-mediated immunity against microbial infection. The inhibition of
IL-12 production by accessory cells after HIV-1 infection has been
identified as a potential factor responsible for impaired innate and
Th1 cell-mediated responses observed in AIDS patients. The mechanism by
which HIV-1 infection suppresses IL-12 gene expression is largely
uncharacterized. Here we review all pathways identified that could
potentially mediate HIV-induced impairment of IL-12 gene expression,
such as IL-10, transforming growth factor ß, interferon-
/ß,
tumor necrosis factor , Fc receptors, complement regulatory
proteins, and receptors. Also discussed is the decreased CD40 ligand
induction in CD4 T cells during HIV infection, which may have a strong
impact on T cell-dependent IL-12 production that is critical for the
establishment and maintenance of a Th1 response.
Key Words: transforming growth factor ß • interferon • tumor necrosis factor
This article has been cited by other articles:
|
|
 |
|
  M. F. Nold, C. A. Nold-Petry, G. B. Pott, J. A. Zepp, M. T. Saavedra, S.-H. Kim, and C. A. Dinarello Endogenous IL-32 Controls Cytokine and HIV-1 Production J. Immunol., July 1, 2008; 181(1): 557 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Majumder, M. L. Janket, E. A. Schafer, K. Schaubert, X.-L. Huang, J. Kan-Mitchell, C. R. Rinaldo Jr., and V. Ayyavoo Human Immunodeficiency Virus Type 1 Vpr Impairs Dendritic Cell Maturation and T-Cell Activation: Implications for Viral Immune Escape J. Virol., July 1, 2005; 79(13): 7990 - 8003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Smed-Sorensen, K. Lore, L. Walther-Jallow, J. Andersson, and A.-L. Spetz HIV-1-infected dendritic cells up-regulate cell surface markers but fail to produce IL-12 p70 in response to CD40 ligand stimulation Blood, November 1, 2004; 104(9): 2810 - 2817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Fantuzzi, C. Purificato, K. Donato, F. Belardelli, and S. Gessani Human Immunodeficiency Virus Type 1 gp120 Induces Abnormal Maturation and Functional Alterations of Dendritic Cells: a Novel Mechanism for AIDS Pathogenesis J. Virol., September 15, 2004; 78(18): 9763 - 9772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mirani, I. Elenkov, S. Volpi, N. Hiroi, G. P. Chrousos, and T. Kino HIV-1 Protein Vpr Suppresses IL-12 Production from Human Monocytes by Enhancing Glucocorticoid Action: Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1 Infection J. Immunol., December 1, 2002; 169(11): 6361 - 6368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Prakash, Z.-Y. Tang, X. Peng, R. Coleman, J. Gill, G. Farr, and F. Samaniego Tumorigenesis and Aberrant Signaling in Transgenic Mice Expressing the Human Herpesvirus-8 K1 Gene J Natl Cancer Inst, June 19, 2002; 94(12): 926 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Ansari, A. E. Mayne, J. B. Sundstrom, P. Bostik, B. Grimm, J. D. Altman, and F. Villinger Administration of Recombinant Rhesus Interleukin-12 during Acute Simian Immunodeficiency Virus (SIV) Infection Leads to Decreased Viral Loads Associated with Prolonged Survival in SIVmac251-Infected Rhesus Macaques J. Virol., February 15, 2002; 76(4): 1731 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Montaner, C.-F. Perno, and S. Crowe Macrophage infection by HIV-1: focus on viral reservoirs and pathogenesis J. Leukoc. Biol., September 1, 2000; 68(3): 301 - 302. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
