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(Journal of Leukocyte Biology. 2000;68:338-344.)
© 2000 by Society for Leukocyte Biology

HIV-1 genotypes in peripheral blood monocytes

Department of Laboratory Medicine, University of Washington, Seattle, Washington

Correspondence: Tuofu Zhu, Department of Laboratory Medicine, University of Washington, PO Box 357110, 1959 NE Pacific Street, Seattle, WA 98195. E-mail: tzhu{at}u.washington.edu

CD4⁺ T cells and tissue macrophages are well defined as the major targets for human immunodeficiency virus type 1 (HIV-1) infection and replication, and their infection accounts for many aspects of HIV-1 pathogenesis in vivo. HIV-1 genotype and phenotype in monocytes and their potential roles in pathogenicity in vivo remain unknown. Herein is an overview of our initial work on HIV-1 genotype in purified CD14⁺ monocytes isolated longitudinally during the course of infection starting from the time of infection. Our data provide evidence for HIV-1 evolution in monocytes and their role as a reservoir of HIV-1 in vivo. A better understanding of HIV-1 in monocytes may greatly help the development of new therapeutic strategies for HIV-1 infection.

Key Words: HIV-1 • genotype • CD14⁺ monocytes

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