HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lalani, A. S. Articles by McFadden, G. Search for Related Content PubMed PubMed Citation Articles by Lalani, A. S. Articles by McFadden, G.

Journal of Leukocyte Biology, Vol 62, Issue 5 570-576, Copyright © 1997 by Society for Leukocyte Biology

JOURNAL ARTICLE

Secreted poxvirus chemokine binding proteins

AS Lalani and G McFadden
Department of Biochemistry, University of Alberta, Edmonton, Canada.

Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 gene and is the first example of what is here referred to as type-I chemokine binding protein (CBP-I). M-T7 was initially discovered as a secreted viral homologue of cellular interferon-gamma receptor but binding studies indicate that purified M-T7 protein also interacts with members of the CXC, CC, and C chemokine families through the conserved heparin-binding domains. The second myxoma protein, M-T1, also called CBP-II, is a member of a larger superfamily of poxvirus proteins that includes related secreted 35-kDa proteins encoded by a wide variety of orthopoxviruses. Deletion analysis of either CBP-I or -II genes within recombinant poxvirus constructs revealed profound alterations in the trafficking of infiltrating leukocytes into virus-infected lesions. It is proposed that the interaction of CBP-I with the conserved heparin-binding domains found on most chemokines represents a novel mechanism for altering multiple chemokine functions in vivo. In summary, CBP-I and CBP-II are the first examples of secreted virus proteins that bind to multiple chemokine family members as part of a strategy to prevent the early phase of inflammatory cell migration into virus-infected tissues.

This article has been cited by other articles:

				U. P. Singh, S. Singh, P. Ravichandran, D. D. Taub, and J. W. Lillard Jr. Viral Macrophage-Inflammatory Protein-II: A Viral Chemokine That Differentially Affects Adaptive Mucosal Immunity Compared with Its Mammalian Counterparts J. Immunol., November 1, 2004; 173(9): 5509 - 5516. [Abstract] [Full Text] [PDF]

				J. W. Lillard Jr, U. P. Singh, P. N. Boyaka, S. Singh, D. D. Taub, and J. R. McGhee MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity Blood, February 1, 2003; 101(3): 807 - 814. [Abstract] [Full Text] [PDF]

				B. T. Seet and G. McFadden Viral chemokine-binding proteins J. Leukoc. Biol., July 1, 2002; 72(1): 24 - 34. [Abstract] [Full Text] [PDF]

				C. Penido, H. C. Castro-Faria-Neto, A. Vieira-de-Abreu, R. T. Figueiredo, A. Pelled, M. A. Martins, P. J. Jose, T. J. Williams, and P. T. Bozza LPS Induces Eosinophil Migration via CCR3 Signaling Through a Mechanism Independent of RANTES and Eotaxin Am. J. Respir. Cell Mol. Biol., December 1, 2001; 25(6): 707 - 716. [Abstract] [Full Text] [PDF]

				C. G. Beck, C. Studer, J.-F. Zuber, B. J. Demange, U. Manning, and R. Urfer The Viral CC Chemokine-binding Protein vCCI Inhibits Monocyte Chemoattractant Protein-1 Activity by Masking Its CCR2B-binding Site J. Biol. Chem., November 9, 2001; 276(46): 43270 - 43276. [Abstract] [Full Text] [PDF]

				J. W. Lillard Jr., P. N. Boyaka, D. D. Taub, and J. R. McGhee RANTES Potentiates Antigen-Specific Mucosal Immune Responses J. Immunol., January 1, 2001; 166(1): 162 - 169. [Abstract] [Full Text] [PDF]

				V. van Berkel, J. Barrett, H. L. Tiffany, D. H. Fremont, P. M. Murphy, G. McFadden, S. H. Speck, and H. W. Virgin IV Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action J. Virol., August 1, 2000; 74(15): 6741 - 6747. [Abstract] [Full Text]

				D. Deane, C. J. McInnes, A. Percival, A. Wood, J. Thomson, A. Lear, J. Gilray, S. Fleming, A. Mercer, and D. Haig Orf Virus Encodes a Novel Secreted Protein Inhibitor of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 J. Virol., February 1, 2000; 74(3): 1313 - 1320. [Abstract] [Full Text]

				A. S. Lalani, J. Masters, W. Zeng, J. Barrett, R. Pannu, H. Everett, C. W. Arendt, and G. McFadden Use of Chemokine Receptors by Poxviruses Science, December 3, 1999; 286(5446): 1968 - 1971. [Abstract] [Full Text]

				A. Carfi, C. A. Smith, P. J. Smolak, J. McGrew, and D. C. Wiley Structure of a soluble secreted chemokine inhibitor vCCI (p35) from cowpox virus PNAS, October 26, 1999; 96(22): 12379 - 12383. [Abstract] [Full Text] [PDF]

				D. V. Pastrana, N. Raghavan, P. FitzGerald, S. W. Eisinger, C. Metz, R. Bucala, R. P. Schleimer, C. Bickel, and A. L. Scott Filarial Nematode Parasites Secrete a Homologue of the Human Cytokine Macrophage Migration Inhibitory Factor Infect. Immun., December 1, 1998; 66(12): 5955 - 5963. [Abstract] [Full Text] [PDF]