Journal of Leukocyte Biology, Vol 59, Issue 2 152-157, Copyright © 1996 by Society for Leukocyte Biology
JOURNAL ARTICLE |
JC Lee and PR Young
SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
A new member of the mitogen-activated protein kinase family, alternatively termed CSBP, p38, or RK, has been identified independently by several laboratories recently. Activation of this novel protein kinase via dual phosphorylation has been observed in different cell systems upon stimulation by a wide spectrum of stimuli, such as physicochemical stress and treatment with lipopolysaccharide or proinflammatory cytokines such as interleukin-1 and tumor necrosis factor. Furthermore, CSAID cytokine biosynthesis inhibitors have now been determined to be potent and selective inhibitors of CSBP/p38/RK kinase activity. These inhibitors will help to dissect signaling pathways involved in inflammatory responses. In particular, for the first time a definitive signal transduction pathway can be prescribed to the action of lipopolysaccharide in cytokine production in macrophages.
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|
|
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|
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 M. Allen, L. Svensson, M. Roach, J. Hambor, J. McNeish, and C. A. Gabel Deficiency of the Stress Kinase P38{alpha} Results in Embryonic Lethality: Characterization of the Kinase Dependence of Stress Responses of Enzyme-Deficient Embryonic Stem Cells J. Exp. Med., March 6, 2000; 191(5): 859 - 870. [Abstract] [Full Text] [PDF]
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G. Zhang, H. Wu, C. R. Ross, J. E. Minton, and F. Blecha Cloning of Porcine NRAMP1 and Its Induction by Lipopolysaccharide, Tumor Necrosis Factor Alpha, and Interleukin-1beta : Role of CD14 and Mitogen-Activated Protein Kinases Infect. Immun., March 1, 2000; 68(3): 1086 - 1093. [Abstract] [Full Text] [PDF]
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G. Hasko, D. G. Kuhel, Z. H. Nemeth, J. G. Mabley, R. F. Stachlewitz, L. Virag, Z. Lohinai, G. J. Southan, A. L. Salzman, and C. Szabo Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock J. Immunol., January 15, 2000; 164(2): 1013 - 1019. [Abstract] [Full Text] [PDF]
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A. L. Hayes, C. Smith, B. M. J. Foxwell, and F. M. Brennan CD45-induced Tumor Necrosis Factor alpha Production in Monocytes Is Phosphatidylinositol 3-Kinase-dependent and Nuclear Factor-kappa B-independent J. Biol. Chem., November 19, 1999; 274(47): 33455 - 33461. [Abstract] [Full Text] [PDF]
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C. M. Thorpe, B. P. Hurley, L. L. Lincicome, M. S. Jacewicz, G. T. Keusch, and D. W. K. Acheson Shiga Toxins Stimulate Secretion of Interleukin-8 from Intestinal Epithelial Cells Infect. Immun., November 1, 1999; 67(11): 5985 - 5993. [Abstract] [Full Text] [PDF]
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A. Mori, O. Kaminuma, K. Miyazawa, K. Ogawa, H. Okudaira, and K. Akiyama p38 Mitogen-Activated Protein Kinase Regulates Human T Cell IL-5 Synthesis J. Immunol., November 1, 1999; 163(9): 4763 - 4771. [Abstract] [Full Text] [PDF]
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A. B. Carter, K. L. Knudtson, M. M. Monick, and G. W. Hunninghake The p38 Mitogen-activated Protein Kinase Is Required for NF-kappa B-dependent Gene Expression. THE ROLE OF TATA-BINDING PROTEIN (TBP) J. Biol. Chem., October 22, 1999; 274(43): 30858 - 30863. [Abstract] [Full Text] [PDF]
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P. De Cesaris, D. Starace, G. Starace, A. Filippini, M. Stefanini, and E. Ziparo Activation of Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Tumor Necrosis Factor alpha Leads to Intercellular Adhesion Molecule-1 Expression J. Biol. Chem., October 8, 1999; 274(41): 28978 - 28982. [Abstract] [Full Text] [PDF]
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 L. Montero and Y. Nagamine Regulation by p38 Mitogen-activated Protein Kinase of Adenylate- and Uridylate-Rich Element-mediated Urokinase-Type Plasminogen Activator (uPA) Messenger RNA Stability and uPA-dependent in Vitro Cell Invasion Cancer Res., October 1, 1999; 59(20): 5286 - 5293. [Abstract] [Full Text] [PDF]
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T. van der Bruggen, S. Nijenhuis, E. van Raaij, J. Verhoef, and B. Sweder van Asbeck Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Monocytes Involves the Raf-1/MEK1-MEK2/ERK1-ERK2 Pathway Infect. Immun., August 1, 1999; 67(8): 3824 - 3829. [Abstract] [Full Text] [PDF]
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P. H. Schafer, S. A. Wadsworth, L. Wang, and J. J. Siekierka p38{alpha} Mitogen-Activated Protein Kinase Is Activated by CD28-Mediated Signaling and Is Required for IL-4 Production by Human CD4+CD45RO+ T Cells and Th2 Effector Cells J. Immunol., June 15, 1999; 162(12): 7110 - 7119. [Abstract] [Full Text] [PDF]
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 S. K. Leeper-Woodford and K. Detmer Acute hypoxia increases alveolar macrophage tumor necrosis factor activity and alters NF-kappa B expression Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L909 - L916. [Abstract] [Full Text] [PDF]
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N. Nath, H. Bian, E. F. Reed, and S. P. Chellappan HLA Class I-Mediated Induction of Cell Proliferation Involves Cyclin E-Mediated Inactivation of Rb Function and Induction of E2F Activity J. Immunol., May 1, 1999; 162(9): 5351 - 5358. [Abstract] [Full Text] [PDF]
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J. J. Baldassare, Y. Bi, and C. J. Bellone The Role of p38 Mitogen-Activated Protein Kinase in IL-1{beta} Transcription J. Immunol., May 1, 1999; 162(9): 5367 - 5373. [Abstract] [Full Text] [PDF]
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A. B. Carter, M. M. Monick, and G. W. Hunninghake Both Erk and p38 Kinases Are Necessary for Cytokine Gene Transcription Am. J. Respir. Cell Mol. Biol., April 1, 1999; 20(4): 751 - 758. [Abstract] [Full Text]
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K. K. Hale, D. Trollinger, M. Rihanek, and C. L. Manthey Differential Expression and Activation of p38 Mitogen-Activated Protein Kinase {alpha}, {beta}, {gamma}, and {delta} in Inflammatory Cell Lineages J. Immunol., April 1, 1999; 162(7): 4246 - 4252. [Abstract] [Full Text] [PDF]
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 M. Wysk, D. D. Yang, H.-T. Lu, R. A. Flavell, and R. J. Davis Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression PNAS, March 30, 1999; 96(7): 3763 - 3768. [Abstract] [Full Text] [PDF]
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M. M. Monick, A. B. Carter, G. Gudmundsson, R. Mallampalli, L. S. Powers, and G. W. Hunninghake A Phosphatidylcholine-Specific Phospholipase C Regulates Activation of p42/44 Mitogen-Activated Protein Kinases in Lipopolysaccharide-Stimulated Human Alveolar Macrophages J. Immunol., March 1, 1999; 162(5): 3005 - 3012. [Abstract] [Full Text] [PDF]
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A. B. Nixon, J. T. O'Flaherty, J. K. Salyer, and R. L. Wykle Acetyl-CoA:1-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine Acetyltransferase Is Directly Activated by p38 Kinase J. Biol. Chem., February 26, 1999; 274(9): 5469 - 5473. [Abstract] [Full Text] [PDF]
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L. E. Palmer, A. R. Pancetti, S. Greenberg, and J. B. Bliska YopJ of Yersinia spp. Is Sufficient To Cause Downregulation of Multiple Mitogen-Activated Protein Kinases in Eukaryotic Cells Infect. Immun., February 1, 1999; 67(2): 708 - 716. [Abstract] [Full Text] [PDF]
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S. K. Manna and B. B. Aggarwal Lipopolysaccharide Inhibits TNF-Induced Apoptosis: Role of Nuclear Factor-{kappa}B Activation and Reactive Oxygen Intermediates J. Immunol., February 1, 1999; 162(3): 1510 - 1518. [Abstract] [Full Text] [PDF]
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P. H. Schafer, L. Wang, S. A. Wadsworth, J. E. Davis, and J. J. Siekierka T Cell Activation Signals Up-Regulate p38 Mitogen-Activated Protein Kinase Activity and Induce TNF-{alpha} Production in a Manner Distinct from LPS Activation of Monocytes J. Immunol., January 15, 1999; 162(2): 659 - 668. [Abstract] [Full Text] [PDF]
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D. D. Browning, N. D. Windes, and R. D. Ye Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation J. Biol. Chem., January 1, 1999; 274(1): 537 - 542. [Abstract] [Full Text] [PDF]
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G. Zybarth, N. Reiling, H. Schmidtmayerova, B. Sherry, and M. Bukrinsky Activation-Induced Resistance of Human Macrophages to HIV-1 Infection In Vitro J. Immunol., January 1, 1999; 162(1): 400 - 406. [Abstract] [Full Text] [PDF]
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M. Bracke, P. J. Coffer, J.-W. J. Lammers, and L. Koenderman Analysis of Signal Transduction Pathways Regulating Cytokine-Mediated Fc Receptor Activation on Human Eosinophils J. Immunol., December 15, 1998; 161(12): 6768 - 6774. [Abstract] [Full Text] [PDF]
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 G. R. Cornelis, A. Boland, A. P. Boyd, C. Geuijen, M. Iriarte, C. Neyt, M.-P. Sory, and I. Stainier The Virulence Plasmid of Yersinia, an Antihost Genome Microbiol. Mol. Biol. Rev., December 1, 1998; 62(4): 1315 - 1352. [Abstract] [Full Text] [PDF]
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L. A. Marshall, M. J. Hansbury, B. J. Bolognese, R. J. Gum, P. R. Young, and R. J. Mayer Inhibitors of the p38 Mitogen-Activated Kinase Modulate IL-4 Induction of Low Affinity IgE Receptor (CD23) in Human Monocytes J. Immunol., December 1, 1998; 161(11): 6005 - 6013. [Abstract] [Full Text] [PDF]
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I. D. McGilvray, Z. Lu, A. C. Wei, A. P. B. Dackiw, J. C. Marshall, A. Kapus, G. Levy, and O. D. Rotstein Murine Hepatitis Virus Strain 3 Induces the Macrophage Prothrombinase fgl-2 through p38 Mitogen-activated Protein Kinase Activation J. Biol. Chem., November 27, 1998; 273(48): 32222 - 32229. [Abstract] [Full Text] [PDF]
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A. G. Borsch-Haubold, S. Pasquet, and S. P. Watson Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059. SB 203580 ALSO INHIBITS THROMBOXANE SYNTHASE J. Biol. Chem., October 30, 1998; 273(44): 28766 - 28772. [Abstract] [Full Text] [PDF]
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K. Miyazawa, A. Mori, H. Miyata, M. Akahane, Y. Ajisawa, and H. Okudaira Regulation of Interleukin-1beta -induced Interleukin-6 Gene Expression in Human Fibroblast-like Synoviocytes by p38 Mitogen-activated Protein Kinase J. Biol. Chem., September 18, 1998; 273(38): 24832 - 24838. [Abstract] [Full Text] [PDF]
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P. K. Vadiveloo, G. Vairo, A. K. Royston, U. Novak, and J. A. Hamilton Proliferation-independent Induction of Macrophage Cyclin D2, and Repression of Cyclin D1, by Lipopolysaccharide J. Biol. Chem., September 4, 1998; 273(36): 23104 - 23109. [Abstract] [Full Text] [PDF]
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C. R. Amura, T. Kamei, N. Ito, M. J. Soares, and D. C. Morrison Differential Regulation of Lipopolysaccharide (LPS) Activation Pathways in Mouse Macrophages by LPS-Binding Proteins J. Immunol., September 1, 1998; 161(5): 2552 - 2560. [Abstract] [Full Text] [PDF]
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P. A. Detmers, D. Zhou, E. Polizzi, R. Thieringer, W. A. Hanlon, S. Vaidya, and V. Bansal Role of Stress-Activated Mitogen-Activated Protein Kinase (p38) in {beta}2-Integrin-Dependent Neutrophil Adhesion and the Adhesion-Dependent Oxidative Burst J. Immunol., August 15, 1998; 161(4): 1921 - 1929. [Abstract] [Full Text] [PDF]
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