Journal of Leukocyte Biology, Vol 58, Issue 6 634-642, Copyright © 1995 by Society for Leukocyte Biology
JOURNAL ARTICLE |
AD Hill, HA Naama, SE Calvano and JM Daly
Department of Surgery, New York Hospital/Cornell University Medical Center, New York 10021, USA.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.
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