Journal of Leukocyte Biology, Vol 57, Issue 4 536-542, Copyright © 1995 by Society for Leukocyte Biology
JOURNAL ARTICLE |
A Rao
Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
The transcription factor NFATp (nuclear factor of activated T cells, preexisting) is likely to regulate the cyclosporin-sensitive transcription of cytokine genes and other activation-associated genes during the immune response. NFATp is the first identified member of a new family of transcription factors, whose DNA binding domains show a weak sequence similarity to those of the Rel (NF-kappa B) family of proteins. NFATp is expressed in several types of immune cells as a cytosolic protein that translocates to the nucleus following activation. The nuclear translocation is regulated by calcium and calcineurin and inhibited by cyclosporin A and FK506. In the nucleus, NFATp cooperates with Fos-Jun dimers and possibly with other transcription factors at composite elements in the regulatory regions of cytokine genes. The potential roles of NFATp and a related family member, NFATc, in cytokine gene transcription are discussed.
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