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Journal of Leukocyte Biology, Vol 55, Issue 6 719-722, Copyright © 1994 by Society for Leukocyte Biology

JOURNAL ARTICLE

In vivo administration of a monoclonal antibody against the type I IL-1 receptor inhibits the ability of mice to eliminate Mycobacterium paratuberculosis

KB Kenefick, JL Adams, H Steinberg and CJ Czuprynski
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison.

The purpose of this study was to determine the influence of endogenous interleukin-1 (IL-1) on resistance to paratuberculosis infection in experimentally infected gnotobiotic mice. Following a 6-month treatment with prednisolone to facilitate bacillary multiplication, control mice substantially reduced the numbers of M. paratuberculosis in the liver and ileum. In contrast, mice injected with a monoclonal antibody against the type I IL-1 receptor failed to reduce the numbers of M. paratuberculosis in the liver and ileum and exhibited more liver granulomas, which contained numerous acid-fast bacilli. These results indicate a significant role for endogenous IL-1 in host defense against experimental M. paratuberculosis infection in mice.


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N. B. Harris and R. G. Barletta
Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine
Clin. Microbiol. Rev., July 1, 2001; 14(3): 489 - 512.
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