Journal of Leukocyte Biology, Vol 55, Issue 5 662-675, Copyright © 1994 by Society for Leukocyte Biology
JOURNAL ARTICLE |
DN Granger and P Kubes
Department of Physiology, LSU Medical Center, Shreveport 71130-3932.
The accumulation of leukocytes in inflamed tissue results from adhesive interactions between leukocytes and endothelial cells within the microcirculation. These adhesive interactions and the excessive filtration of fluid and protein that accompanies an inflammatory response are largely confined to one region of the microvasculature: postcapillary venules. The nature and magnitude of the leukocyte-endothelial cell adhesive interactions that take place within postcapillary venules are determined by a variety of factors, including expression of adhesion molecules on leukocytes and/or endothelial cells, products of leukocyte (superoxide) and endothelial cell (nitric oxide) activation, and the physical forces generated by the movement of blood along the vessel wall. The contribution of different adhesion molecules to leukocyte rolling, adherence, and emigration in venules is discussed. Emerging views on potential endogenous antiadhesion molecules produced by endothelial cells as well as the influence of alterations in shear rate on leukocyte adhesion are addressed. Finally, the pathophysiological significance of the microvascular responses to inflammation are discussed in terms of adhesion-directed strategies for the treatment of different cardiovascular diseases and circulatory disorders.
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|
|
|
|
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|
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|
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|
|
 |
|
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|
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 |
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P. Bauer, C. W. Lush, P. R. Kvietys, J. M. Russell, and D. N. Granger Role of endotoxin in the expression of endothelial selectins after cecal ligation and perforation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1140 - R1147. [Abstract] [Full Text] [PDF]
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|
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P. He, J. Wang, and M. Zeng Leukocyte adhesion and microvessel permeability Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1686 - H1694. [Abstract] [Full Text] [PDF]
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S. Seveau, H. Keller, F. R. Maxfield, F. Piller, and L. Halbwachs-Mecarelli Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule Blood, April 15, 2000; 95(8): 2462 - 2470. [Abstract] [Full Text] [PDF]
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P. K. Henke, L. A. DeBrunye, R. M. Strieter, J. S. Bromberg, M. Prince, A. M. Kadell, M. Sarkar, F. Londy, and T. W. Wakefield Viral IL-10 Gene Transfer Decreases Inflammation and Cell Adhesion Molecule Expression in a Rat Model of Venous Thrombosis J. Immunol., February 15, 2000; 164(4): 2131 - 2141. [Abstract] [Full Text] [PDF]
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S. Fukuda, T. Yasu, D. N. Predescu, and G. W. Schmid-Schonbein Mechanisms for Regulation of Fluid Shear Stress Response in Circulating Leukocytes Circ. Res., January 7, 2000; 86 (1): e13 - e18. [Abstract] [Full Text] [PDF]
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E. Saavedra, M. Herrera, W. Gao, H. Uemura, and M. A. Pereira The Trypanosoma cruzi trans-Sialidase, through Its Cooh-Terminal Tandem Repeat, Upregulates Interleukin 6 Secretion in Normal Human Intestinal Microvascular Endothelial Cells and Peripheral Blood Mononuclear Cells J. Exp. Med., December 20, 1999; 190(12): 1825 - 1836. [Abstract] [Full Text] [PDF]
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A Tailor, A Tomlinson, A Salas, J Panes, D N Granger, R J Flower, and M Perretti Dexamethasone inhibition of leucocyte adhesion to rat mesenteric postcapillary venules: role of intercellular adhesion molecule 1 and KC Gut, November 1, 1999; 45(5): 705 - 712. [Abstract] [Full Text] [PDF]
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S. Kawachi, A. Cockrell, F. S. Laroux, L. Gray, D. N. Granger, H. C. van der Heyde, and M. B. Grisham Role of inducible nitric oxide synthase in the regulation of VCAM-1 expression in gut inflammation Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G572 - G576. [Abstract] [Full Text] [PDF]
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E. von Dobschuetz, T. Hoffmann, and K. Messmer Inhibition of Neutrophil Proteinases by Recombinant Serpin Lex032 Reduces Capillary No-Reflow in Ischemia/Reperfusion-Induced Acute Pancreatitis J. Pharmacol. Exp. Ther., August 1, 1999; 290(2): 782 - 788. [Abstract] [Full Text]
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 |
|
 M. Ishikawa, E. Sekizuka, S. Sato, N. Yamaguchi, J. Inamasu, H. Bertalanffy, T. Kawase, and C. Iadecola Effects of Moderate Hypothermia on Leukocyte- Endothelium Interaction in the Rat Pial Microvasculature After Transient Middle Cerebral Artery Occlusion • Editorial Comment Stroke, August 1, 1999; 30(8): 1679 - 1686. [Abstract] [Full Text] [PDF]
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N. Miyamoto, M. Mandai, I. Suzuma, K. Suzuma, K. Kobayashi, and Y. Honda Estrogen Protects Against Cellular Infiltration by Reducing the Expressions of E-Selectin and IL-6 in Endotoxin-Induced Uveitis J. Immunol., July 1, 1999; 163(1): 374 - 379. [Abstract] [Full Text] [PDF]
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S. Shigematsu, S. Ishida, D. C. Gute, and R. J. Korthuis Concentration-dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesentery Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H152 - H160. [Abstract] [Full Text] [PDF]
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S. Shigematsu, S. Ishida, D. C. Gute, and R. J. Korthuis Bradykinin prevents postischemic leukocyte adhesion and emigration and attenuates microvascular barrier disruption Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H161 - H171. [Abstract] [Full Text] [PDF]
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 |
|
 G. A. Zimmerman, K. H. Albertine, H. J. Carveth, E. A. Gill, C. K. Grissom, J. R. Hoidal, T.-a. Imaizumi, C. G. Maloney, T. M. McIntyre, J. R. Michael, et al. Endothelial Activation in ARDS Chest, July 1, 1999; 116 (2009): 18S - 24S. [Full Text]
|
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|
|
|
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R. SCALIA, G. BOOTH, and D. J. LEFER Vascular endothelial growth factor attenuates leukocyte–endothelium interaction during acute endothelial dysfunction: essential role of endothelium-derived nitric oxide FASEB J, June 1, 1999; 13(9): 1039 - 1046. [Abstract] [Full Text]
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J. Carvalho-Tavares, A. Fox-Robichaud, and P. Kubes Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G828 - G834. [Abstract] [Full Text] [PDF]
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|
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M. Casadevall, E. Saperas, J. Panes, A. Salas, D. C. Anderson, J. R. Malagelada, and J. M. Pique Mechanisms underlying the anti-inflammatory actions of central corticotropin-releasing factor Am J Physiol Gastrointest Liver Physiol, April 1, 1999; 276(4): G1016 - G1026. [Abstract] [Full Text] [PDF]
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Q. Dong, K. A. Siminovitch, L. Fialkow, T. Fukushima, and G. P. Downey Negative Regulation of Myeloid Cell Proliferation and Function by the SH2 Domain-Containing Tyrosine Phosphatase-1 J. Immunol., March 15, 1999; 162(6): 3220 - 3230. [Abstract] [Full Text] [PDF]
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S. Kanwar, D. A. Steeber, T. F. Tedder, M. J. Hickey, and P. Kubes Overlapping Roles for L-Selectin and P-Selectin in Antigen-Induced Immune Responses in the Microvasculature J. Immunol., March 1, 1999; 162(5): 2709 - 2716. [Abstract] [Full Text] [PDF]
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J. A. Hobden, S. Masinick-McClellan, R. P. Barrett, K. S. Bark, and L. D. Hazlett Pseudomonas aeruginosa Keratitis in Knockout Mice Deficient in Intercellular Adhesion Molecule 1 Infect. Immun., February 1, 1999; 67(2): 972 - 975. [Abstract] [Full Text] [PDF]
|
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N Mori, Y Horie, M E Gerritsen, D C Anderson, and D N Granger Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds Gut, February 1, 1999; 44(2): 186 - 195. [Abstract] [Full Text] [PDF]
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|
|
|
 |
|
 G Cepinskas, M Sandig, and P. Kvietys PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front J. Cell Sci., January 6, 1999; 112(12): 1937 - 1945. [Abstract] [PDF]
|
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|
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|
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T. J. Kalogeris, C. G. Kevil, F. S. Laroux, L. L. Coe, T. J. Phifer, and J. S. Alexander Differential monocyte adhesion and adhesion molecule expression in venous and arterial endothelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 1999; 276(1): L9 - L19. [Abstract] [Full Text] [PDF]
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|
|
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N. Harada, K. Okajima, S. Kushimoto, H. Isobe, and K. Tanaka Antithrombin Reduces Ischemia/Reperfusion Injury of Rat Liver by Increasing the Hepatic Level of Prostacyclin Blood, January 1, 1999; 93(1): 157 - 164. [Abstract] [Full Text] [PDF]
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S. S. Yadav, D. N. Howell, W. Gao, D. A. Steeber, R. C. Harland, and P.-A. Clavien L-selectin and ICAM-1 mediate reperfusion injury and neutrophil adhesion in the warm ischemic mouse liver Am J Physiol Gastrointest Liver Physiol, December 1, 1998; 275(6): G1341 - G1352. [Abstract] [Full Text] [PDF]
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R. Hayward and A. M. Lefer Time course of endothelial-neutrophil interaction in splanchnic artery ischemia-reperfusion Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H2080 - H2086. [Abstract] [Full Text] [PDF]
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L. H. K. Lim, E. Solito, F. Russo-Marie, R. J. Flower, and M. Perretti Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: Effect of lipocortin 1 PNAS, November 24, 1998; 95(24): 14535 - 14539. [Abstract] [Full Text] [PDF]
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A. Salas, J. Panes, J. I. Elizalde, M. Casadevall, D. C. Anderson, D. N. Granger, and J. M. Pique Mechanisms responsible for enhanced inflammatory response to ischemia-reperfusion in diabetes Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1773 - H1781. [Abstract] [Full Text] [PDF]
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K. A. Skinner, C. R. White, R. Patel, S. Tan, S. Barnes, M. Kirk, V. Darley-Usmar, and D. A. Parks Nitrosation of Uric Acid by Peroxynitrite. FORMATION OF A VASOACTIVE NITRIC OXIDE DONOR J. Biol. Chem., September 18, 1998; 273(38): 24491 - 24497. [Abstract] [Full Text] [PDF]
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