Accuri C6 Flow Cytometer System

This Article
Right arrow Full Text (PDF) Free
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kuroki, M.
Right arrow Articles by Matsuoka, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuroki, M.
Right arrow Articles by Matsuoka, Y.

Journal of Leukocyte Biology, Vol 52, Issue 5 551-557, Copyright © 1992 by Society for Leukocyte Biology

JOURNAL ARTICLE

Augmented expression and release of nonspecific cross-reacting antigens (NCAs), members of the CEA family, by human neutrophils during cell activation

M Kuroki, Y Matsuo, T Kinugasa and Y Matsuoka
Department of Biochemistry, School of Medicine, Fukuoka University, Japan.

Nonspecific cross-reacting antigens (NCAs) are a group of human glycoproteins immunologically cross-reactive with carcinoembryonic antigen (CEA). Our previous studies have shown that at least seven NCA glycoproteins different in molecular weight and antigenic reactivity, including a species corresponding to CD67, can be detected in neutrophil granulocytes. In the present paper, it is demonstrated that neutrophil activation induced with soluble stimulators, the calcium ionophore A23187, N-formylmethionyl-leucyl-phenylalanine, and phorbol myristate acetate, results in augmented release and cell surface expression of NCAs. The NCA release was correlated with the discharge of azurophil granules but not with that of specific granules and was attributable to the release of NCA species of 53 and 30 kd. The increased NCA expression on the cell surface was due to increments of the NCAs of 160, 100 (CD67), 95, 90, 30, and 26 kd. These results, together with the previous findings that the CEA family members can mediate intercellular adhesion and bind Escherichia coli in vitro, imply that the neutrophil NCAs participate in the functions of neutrophils such as phagocytosis, chemotaxis, and adherence.


This article has been cited by other articles:


Home page
 Reproductive SciencesHome page
C. E. Leik and S. W. Walsh
Systemic Activation and Vascular Infiltration of Neutrophils With Term Labor
Reproductive Sciences, September 1, 2006; 13(6): 425 - 429.
[Abstract] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Kuroki, H. Abe, T. Imakiirei, S. Liao, H. Uchida, Y. Yamauchi, S. Oikawa, and M. Kuroki
Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8
J. Leukoc. Biol., October 1, 2001; 70(4): 543 - 550.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M.A Costa, L.E.A de Wit, V de Valk, P Serrano, A.J Wardeh, P.W Serruys, and W Sluiter
Indirect evidence for a role of a subpopulation of activated neutrophils in the remodelling process after percutaneous coronary intervention
Eur. Heart J., April 1, 2001; 22(7): 580 - 586.
[Abstract] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Dettke, G. Pálfi, and H. Loibner
Activation-dependent expression of the blood group-related Lewis Y antigen on peripheral blood granulocytes
J. Leukoc. Biol., October 1, 2000; 68(4): 511 - 514.
[Abstract] [Full Text]

Home page
 BloodHome page
A.-M. Eades-Perner, J. Thompson, H. van der Putten, and W. Zimmermann
Mice Transgenic for the Human CGM6 Gene Express Its Product, the Granulocyte Marker CD66b, Exclusively in Granulocytes
Blood, January 15, 1998; 91(2): 663 - 672.
[Abstract] [Full Text] [PDF]